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TranscriptomicsGenome-wide analysis identifies aberrant methylation in Fragile X syndrome is specific to the FMR1 locus
Fragile X syndrome (FXS) is a common form of inherited intellectual disability and is caused by an expansion of CGG repeats located in the 5Õ untranslated region (UTR) of the FMR1 gene, leading to hypermethylation and silencing of this locus. While the dramatic increase in DNA methylation (DNAm) of ...
ORGANISM(S): Homo sapiens 
2013-04-15 | E-GEOD-41273 | biostudies-arrayexpress
TranscriptomicsArray-based assay detects genome-wide 5-methylcytosine and 5-hydroxymethlycytosine in non-human primates and mice
Murine and non-human primates (e.g. rhesus monkeys) represent excellent model systems to study human health and disease. However, use of these model systems for genomic studies is limited, particularly with array-based tools, as most have only been developed to survey the human genome. Here we prese...
ORGANISM(S): Macaca mulatta 
2014-02-06 | E-GEOD-49177 | biostudies-arrayexpress
TranscriptomicsPediatric age-associated DNA methylation
DNA methylation (DNAm) plays diverse roles in human biology, but this dynamic epigenetic mark remains far from fully characterized. Although earlier studies uncovered loci that undergo age-associated DNAm changes in adults, little is known about such changes during childhood. Despite profound DNAm p...
ORGANISM(S): Homo sapiens 
2012-02-01 | E-GEOD-27097 | biostudies-arrayexpress
TranscriptomicsMethylation Profiling of Blood DNA from Sibling Discordant for Autism
Analysis of the methylation level of 27,578 CpG dinucleotides in DNA derived from peripheral blood leukocytes from autistic children and unaffected siblings was conducted using the Illumina HumanMeth27 BeadChip DNA methylation association study for autistic and non-autistic siblings
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-27044 | biostudies-arrayexpress
TranscriptomicsMethylation Profiling of Blood DNA from Healthy Children
Analysis of the DNA methylation level in peripheral blood leukocytes from healthy children using the Illumina HumanMethylation450 BeadChip Groupings by family membership requested but not provided by submitter DNA methylation association study in healthy children
ORGANISM(S): Homo sapiens 
2015-02-16 | E-GEOD-36054 | biostudies-arrayexpress
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