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TranscriptomicsIGR_U753_MELANOMA_SC_STUDY_ZN
Melanoma cells from three surgical specimens of nodular melanoma were grown as anchorage-independent melanospheres in stem cell bFGF(+)EGF(+) medium and as adherent monolayer cultures in the presence of serum. RNA from melanospheres (DMBC2s, DMBC8s, DMBC10s) and their adherent monolayer counterparts...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-MTAB-1869 | biostudies-arrayexpress
TranscriptomicsAXL targeting overcomes human lung cancer cell resistance to NK and CTL-mediated cytotoxicity
To investigate the effect of AXL inhibition on gene expression in carcinoma cell clones derived from NSCLC IGR-Heu cells, we profiled gene expression in cells treated with the AXL inhibitor bemcentinib (1 µmol/L) or with vehicle (dmso) for 72 hours
ORGANISM(S): Homo sapiens 
2019-10-25 | E-MTAB-8294 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of humoral resistance to the CTL after phenotypical and functional study of the resistant clone IGR-HeuR8
From a tumoral line IGR-Heu; resulting from a biopsy of the primitive tumour of a patient reached of a bronchial cancer not with small cells (NSCLC); we established; by successive co-cultures of this line with the autologous CTL (clone T H161); a resistant line to the cytotoxic lysis induced by H16...
ORGANISM(S): Homo sapiens 
2006-01-23 | E-TABM-71 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human TRAIL-resistant metastatic vs primary TRAIL-sensitive melanoma cells
T1 and G1 are the two melanoma cell lines, established from primary tumor (T1) and lymph node metastases (G1) of a 77 years old male patient. While G1 cells were resistant to TRAIL (TNF-related apoptosis-inducing ligand) mediated cell death, T1 cells exhibited a high dose- and time-dependent sensiti...
ORGANISM(S): Homo sapiens 
2006-01-01 | E-MEXP-247 | biostudies-arrayexpress
TranscriptomicsmiR-181a modulates Acute Myeloid Leukemia susceptibility to natural killer cells
Overexpression of miR-181a in AML blasts: DNA Microarray was performed to compare overall gene expression profiles of KG-1 Anti-miR-CT and U937 Anti-miR-CT cells compared respectively to KG-1 Anti-miR-181a and U937 Anti-miR-181a.
ORGANISM(S): Homo sapiens 
2014-12-30 | E-MTAB-2837 | biostudies-arrayexpress
TranscriptomicsSelection of tumor resistant variants following sustained NK-mediated immune stress
Resistance of tumor cells to cell-mediated cytotoxicity remains a drawback in the immunotherapy of cancer and its molecular basis is poorly understood. To investigate the acquisition of tumor resistance to cell-mediated cytotoxicity, resistant variants were selected following long term NK cell selec...
ORGANISM(S): Homo sapiens 
2020-11-02 | E-MTAB-8777 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human T cell lines isolated from tumor infiltrating lymphocytes or peripheral blood lymphocytes of a patient with large cell carcinoma of the lung
The IGR-Heu tumor cell line was established from patient Heu suffering from large cell carcinoma of the lung. Heu171, Heu127 and Heu161 T cell clones were isolated from autologous tumor infiltrating lymphocytes. H32 T cell line and H32-22 clone were isolated from autologous PBL after stimulation wit...
ORGANISM(S): Homo sapiens 
2007-03-02 | E-TABM-208 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human T cell lines isolated from tumor infiltrating lymphocytes or peripheral blood lymphocytes of a patient with large cell carcinoma of the lung
The IGR-Heu tumor cell line was established from patient Heu suffering from large cell carcinoma of the lung. Heu171 T cell clones were isolated from autologous tumor infiltrating lymphocytes. H32-22 clone was isolated from autologous peripheral blood lymphocytes after stimulation with IGR-Heu and...
ORGANISM(S): Homo sapiens 
2007-03-02 | E-TABM-207 | biostudies-arrayexpress
TranscriptomicsIGR_NANBAKHSH_HOXB4
We have previously shown that human umbilical cord blood CD34+ progenitor cells undergo in vitro differentiation into functional NK cells and that their co-culture in the presence of HOXB4 transduced stromal MS5 cells resulted in an increase in differentiated NK number. The present study was conduct...
ORGANISM(S): Homo sapiens 
2014-06-07 | E-MTAB-1710 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lung large cell carncinoma cells grown under hypoxic conditions and treated with STAT3 siRNA
Hypoxia-mediated inhibition of specific tumour cell lysis
ORGANISM(S): Homo sapiens 
2009-03-12 | E-TABM-611 | biostudies-arrayexpress
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