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ProteomicsA quantitative tissue-specific landscape of protein redox regulation during aging
Mammalian tissues engage in specialized physiology that is regulated by post-translational protein modification. A major mode of protein regulation is initiated by reactive oxygen species (ROS) that reversibly modify protein cysteine residues. ROS regulate a myriad of biological processes and ROS ...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-27 | PXD017050 | Pride
Cpt Redox Aging Cysteine proteomics 
ProteomicsArchitecture of the outbred brown fat proteome defines regulators of metabolic physiology
Obesity is a polygenic disorder with variable penetrance in the general population. Brown adipose tissue (BAT) is a major regulator of energy expenditure and metabolic physiology due to a specialized proteome that orchestrates futile metabolic cycles, which could be leveraged to treat obesity. Howev...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-08 | PXD036947 | Pride
Diversity outbred Qtl Physiology Metabolic disease Network Proteome Obesity Phenotype 
MetabolomicsGNPS - Metabolite-protein covariation architecture identified a cysteine shunt regulating liver cholesterol
Metabolomics raw data for manuscript Xiao, H. et al. "Metabolite-protein covariation architecture identified a cysteine shunt regulating liver cholesterol".
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2025-06-24 | MSV000098306 | GNPS
ProteomicsLactate regulates cell cycle and proliferation by remodeling the anaphase promoting complex
Lactate is abundant in rapidly dividing cells, due to the requirement for elevated glucose catabolism to support proliferation. However, it is not known whether accumulated lactate affects the proliferative state. Here, we deploy a systematic approach to determine lactate-dependent regulation of pro...
ORGANISM(S): Homo sapiens (Human) 
2023-02-07 | PXD036641 | Pride
Tpp Lactate Cell cycle 
Proteomics"Metabolite-protein covariation architecture identified a cysteine shunt regulating liver cholesterol
Metabolomics raw data for manuscript Xiao, H. et al. "Metabolite-protein covariation architecture identified a cysteine shunt regulating liver cholesterol".
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2025-06-24 | MSV000098306 | MassIVE
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