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MetabolomicsSex-specific effects of CD248 on metabolism and the adipose tissue lipidome

Cd248 has recently been associated with adipose tissue physiology, demonstrated by reduced weight gain in high fat diet-fed mice with genetic deletion of Cd248 relative to controls. Here we set out to determine the metabolic consequences of loss of Cd248. Strikingly, we find these to be sex speci...

2023-01-05 | MTBLS6615 | MetaboLights
Transcriptomicsm6A RNA methylation promotes XIST-mediated transcriptional repression
XIST is a long non-coding RNA (lncRNA) that mediates transcriptional silencing of X chromosome genes. Here we show that XIST is highly methylated with at least 78 N6-methyladenosine (m6A) residues, a reversible base modification whose function in lncRNAs is unknown. We show that m6A formation in XIS...
ORGANISM(S): Homo sapiens 
2016-09-07 | E-GEOD-78030 | biostudies-arrayexpress
TranscriptomicsBreast cancer cell lines treated with eribulin and paclitaxel
Eribulin mesylate is a synthetic macrocyclic ketone analog of the marine sponge natural product halichondrin B. Eribulin is a mechanistically unique inhibitor of microtubule dynamics, leading to inhibition of microtubule growth in the absence of effects on microtubule shortening at microtubule plus ...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-50811 | biostudies-arrayexpress
TranscriptomicsMiRNA expression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes
MicroRNAs (miRNAs) are non-coding RNA molecules involved in post-transcriptional control of gene expression of a wide number of genes, including those involved in glucose homeostasis. Type 2 diabetes (T2D) is characterized by hyperglycaemia and defects in insulin secretion and action at target tissu...
ORGANISM(S): Rattus norvegicus 
2010-05-16 | E-GEOD-17058 | biostudies-arrayexpress
UnknownAntitumor Activity of Pembrolizumab in Biomarker-Unselected Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Results From the Phase Ib KEYNOTE-012 Expansion Cohort.
Not available
S-EPMC6804896 | biostudies-literature
TranscriptomicsTranscription profiling of mouse gene expression after transverse aortic constriction in mice: comparison of TAC vs. sham group at 2, 10 and 21 days to identify the differential expression of genes
Microarray analysis of gene expression after transverse aortic constriction in mice: comparison of TAC vs. sham group at 48 hours, 10 days, and 3 weeks.
ORGANISM(S): Mus musculus 
2007-10-12 | E-GEOD-1621 | biostudies-arrayexpress
TranscriptomicsEndometrial cancer cell lines treated with eribulin and paclitaxel
Eribulin mesylate is a synthetic macrocyclic ketone analog of the marine sponge natural product halichondrin B. Eribulin is a mechanistically unique inhibitor of microtubule dynamics, leading to inhibition of microtubule growth in the absence of effects on microtubule shortening at microtubule plus ...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-50830 | biostudies-arrayexpress
TranscriptomicsOvarian cancer cell lines treated with eribulin and paclitaxel
Eribulin mesylate is a synthetic macrocyclic ketone analog of the marine sponge natural product halichondrin B. Eribulin is a mechanistically unique inhibitor of microtubule dynamics, leading to inhibition of microtubule growth in the absence of effects on microtubule shortening at microtubule plus ...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-50831 | biostudies-arrayexpress
GenomicsInternational Standards for Cytogenomic Arrays

The International Standards for Cytogenomic Arrays (ISCA) Consortium is a rapidly growing group of clinical cytogenetics and molecular genetics laboratories committed to improving quality of patient care related to clinical genetic testing using new molecular cytogenetic technologies including ar...

phs000205.v4.p2 | EGA
UnknownaMPT and amphetamine ameliorate hyperactivity in a novel mouse model of DTDS
Not available
S-SCDT-10_1038-S44321-026-00381-0 | biostudies-other
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