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MetabolomicsSalmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on...

2024-05-22 | MTBLS2347 | MetaboLights
MetabolomicsZhaqu Compound Improves Glucose and Lipid Metabolism in T2DM with MASLD by Modulating Gut Microbiota and PPARγ

Type 2 diabetes mellitus (T2DM) with metabolic syndrome-associated steatohepatitis (MASLD) is a complex metabolic comorbidity characterized by hyperglycemia, pancreatic β-cell dysfunction, and hepatic lipid metabolism disorders, in which gut microbiota dysbiosis and abnormal PPARγ signaling play ...

2026-02-25 | MTBLS13933 | MetaboLights
TranscriptomicsExpression data from B6 mouse miR-142 KO and WT T cells
T cells are critical for modulating immune responses. miRNAs are small, noncoding RNAs and play a significant role in T cell responses. miR-142 is a hematopoietic specific miRNA. To explore the potential role of miR-142 in regulating T cell responses, we generated mutant mice bearing a targeted de...
ORGANISM(S): Mus musculus 
2014-05-13 | E-GEOD-57543 | biostudies-arrayexpress
TranscriptomicsGene expression in chow or HFD-fed OGG1-/- livers
Gene expression in livers of male wild-type (WT) and OGG1-deficient (Ogg1-/-) mice fed either a chow diet or a high-fat diet (HFD) were examined. Mice were fed the diet for 10 weeks prior to tissue collection and were 22 weeks of age at the time of tissue collection. 24 Total samples were analyzed. ...
ORGANISM(S): Mus musculus 
2012-12-16 | E-GEOD-35497 | biostudies-arrayexpress
TranscriptomicsDigoxin and its derivatives suppress Th17 cell differentiation by antagonizing RORγt activity
CD4+ T helper lymphocytes that express interleukin-17 (Th17 cells) have critical roles in mouse models of autoimmunity, and there is mounting evidence that they also influence inflammatory processes in humans. Genome-wide association studies in humans have linked genes involved in Th17 cell differe...
ORGANISM(S): Mus musculus 
2011-03-28 | E-GEOD-27241 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of adipose samples from LDLR-/- mice to study response to anti-diabetic drug and dietary lifestyle interventions
Lean male mice were fed a high fat diet (HFD, lard 24% w/w) for 16 weeks. At 9 weeks, when all hallmarks of prediabetes were established, groups of mice were treated with drug (rosiglitazone, pioglitazone, T0901317, or salicylate) for another 7 weeks together with the high fat diet. An additional gr...
ORGANISM(S): Mus musculus 
2014-05-14 | E-GEOD-57659 | biostudies-arrayexpress
TranscriptomicsTranscript atlases reveal that artery tertiary lymphoid organs but not secondary lymphoid organs control key steps of atherosclerosis T cell immunity in aged apoe-/- mice.
Tertiary lymphoid organs (TLOs) emerge in response to nonresolving inflammation but their roles in adaptive immunity remain unknown. Here, we explored artery TLOs (ATLOs) to delineate atherosclerosis T cell responses in apoe-/- mice during aging. Though the T cell repertoire showed systemic age-asso...
ORGANISM(S): Mus musculus 
2013-10-30 | E-GEOD-40156 | biostudies-arrayexpress
GenomicsHyperlipidemia elicits an IFN-based CD4+ T cell response
Hyperlipidemia elicits an IFN-based CD4+ T cell response
PRJNA808093 | ENA
GenomicsSingle cell sequencing of murine CD4+ T cells from atherosclerotic aortas
Single cell sequencing of murine CD4+ T cells from atherosclerotic aortas
PRJNA627239 | ENA
GenomicsExpression profiling of murine hepatic CD4+ T cells using NanoString nCounter assay
Expression profiling of murine hepatic CD4+ T cells using NanoString nCounter assay
PRJNA1285981 | ENA
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