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TranscriptomicsTranscription profiling of S. pombe reveals Cyclin dependent kinase inhibits re-initiation of a normal S-phase program during G2
To achieve faithful replication of the genome once in each cell cycle, re-initiation of S-phase is prevented in G2 and origins are restricted from re-firing within S-phase. We have investigated the block to re-replication during G2 in fission yeast. The DNA synthesis that occurs when G2/M cyclin d...
ORGANISM(S): Schizosaccharomyces pombe 
2009-05-13 | E-MTAB-105 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of S. pombe co-overexpressing DNA synthesis initiation factors cdc18 (cdc6) and cdt1 to investigate gene copy number increases
During S-phase of the eukaryotic cell cycle, controls exist to ensure that replication origins fire only once and become inactivated after traverse of a replication fork. Failure of these controls results in local amplification of the genome which can lead to gene copy increases important for both ...
ORGANISM(S): Schizosaccharomyces pombe 
2010-08-13 | E-MTAB-139 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Vitis vinifera cv. Cabernet-Sauvignon leaves obtained from plants grown in different enviroments and infected with vascular ascomycete fungus Eutypa lata.
Eutypa dieback is a vascular disease that may severely affect vineyards throughout the world. In the present work, microarrays analysis were made in order (i) to improve our knowledge of grapevine (Vitis vinifera cv. Cabernet-Sauvignon) responses to Eutypa lata, the causal agent of Eutypa dieback an...
ORGANISM(S): Vitis vinifera 
2010-03-01 | E-MEXP-2337 | biostudies-arrayexpress
TranscriptomicsGene expression profiling after vaccination with the RTS,S candidate malaria vaccine in a controlled human malaria infection study
RTS,S is the sole candidate vaccine shown to provide protection against infection to malaria-naive adults challenged with mosquito-borne homologous falciparum malaria and protection against infection and clinical and severe disease to volunteers in malaria-endemic Africa who were exposed to diverse ...
ORGANISM(S): Homo sapiens 
2017-04-27 | E-MTAB-4629 | biostudies-arrayexpress
TranscriptomicsTranscript analysis of Arabidopsis wild type and S-nitrosoglutathione reductase knock-out line (Wassilewskija)
Nitric oxide (NO) is a signaling molecule that participates in diverse developmental processes in plants, and in responses to abiotic and biotic stresses. The main mode of action of NO is protein S-nitrosylation, the post-translational modification of thiol residues. S-nitrosoglutathione (GSNO) as a...
ORGANISM(S): Arabidopsis thaliana 
2017-04-30 | E-MTAB-4756 | biostudies-arrayexpress
GenomicsChromatin maps of the Drosophila melanogaster TrxG protein Ash1 and FSH
Trithorax group (TrxG) proteins counteract Polycomb silencing by an as yet uncharacterized mechanism. A well-known member of the TrxG is the histone methyltransferase Absent, Small, or Homeotic discs 1 (ASH1). In Drosophila ASH1 is needed for the maintenance of Hox gene expression throughout develop...
ORGANISM(S): Drosophila melanogaster 
2013-06-30 | E-GEOD-30820 | biostudies-arrayexpress
GenomicsHog1 controls global reallocation of RNA Pol II upon osmotic shock
When challenged with osmotic shock, S. cerevisiae induces hundreds of genes, despite a global reduction in transcriptional capacity. The mechanisms that regulate this rapid reallocation of transcriptional resources are not known. Here we show that redistribution of RNA Pol II upon stress requires ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-07-15 | E-GEOD-38208 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of late ripening stages of grapevine berry
Background: The composition of grapevine berry at harvest is a major determinant of wine quality. Optimal oenological maturity of berries is characterized by a high sugar/acidity ratio, high anthocyanin content in the skin, and low astringency. However, harvest time is still mostly determined empiri...
ORGANISM(S): Vitis vinifera 
2011-11-08 | E-MTAB-481 | biostudies-arrayexpress
no omics definedTranscription profiling of teicoplanin-susceptible strain of S.aureus and its teicoplanin-resistant derivative
Changes in transcriptome of S. aureus linked with acquisition of teicoplanin resistance and reduced autolysis. Comparison of RNA profiling of the teicoplanin-susceptible parental strain (MRGR3)with its teicoplanin-resistant derivative (14-4).
ORGANISM(S): Staphylococcus aureus 
2007-01-01 | E-MEXP-738 | biostudies-arrayexpress
TranscriptomicsComparison of L-carnitine treated day 6 in vivo bovine embryos to controls, in both the Jersey and Holstein breeds.
The decreased rate of pregnancy obtained in cattle using frozen in vitro embryos compared to in vivo embryos has been associated with over-accumulation of intracellular lipid, which causes cell damage during cryopreservation. It is believed that the higher lipid content of blastomeres of bovine embr...
ORGANISM(S): Bos taurus 
2014-10-23 | E-GEOD-62595 | biostudies-arrayexpress
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