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TranscriptomicsTranscription profiling of mouse embryonic stem cell line mESC D3 reveals cardiac differentiation of embryonic stem cells recapitulates embryonic cardiac development.
Mouse embryonic stem cells can differentiate in vitro into spontaneously contracting cardiomyocytes. The main objective of this study was to investigate cardiogenesis in cultures of differentiating embryonic stem cells (ESCs) and to determine how closely it mimics in vivo cardiac development. We ide...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5671 | biostudies-arrayexpress
ProteomicsDUX4 expression activates JNK and p38 MAP kinases in myoblasts
Facioscapulohumoral muscular dystrophy (FSHD) is caused by misexpression of the DUX4 transcription factor in skeletal muscle that results in transcriptional alterations, abnormal phenotypes, and cell death. To gain insight into the kinetics of DUX4-induced stresses, we activated DUX4 expression in m...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-07-05 | MSV000089812 | MassIVE
TranscriptomicsTranscription factors MYOCD, SRF, Mesp1 and SMARCD3 significantly enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming
Transient over-expression of defined combinations of master regulator genes can effectively induce cellular reprogramming: the acquisition of an alternative predicted phenotype from a differentiated cell lineage. This can be of particular importance in cardiac regenerative medicine wherein the heart...
ORGANISM(S): Mus musculus 
2013-03-31 | E-GEOD-44401 | biostudies-arrayexpress
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