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TranscriptomicsCopy number variation in the genomes of twelve natural isolates of Caenorhabditis elegans
Background: Copy number variation is an important component of genetic variation in higher eukaryotes. The extent of natural copy number variation in C. elegans is unknown outside of 2 highly divergent wild isolates and the canonical N2 Bristol strain. Results: We have used array comparative genomic...
ORGANISM(S): Caenorhabditis elegans 
2010-05-17 | E-GEOD-19440 | biostudies-arrayexpress
TranscriptomicsCopy number variation in the bovine genome
Copy number variations (CNVs), which represent a significant source of genetic diversity in mammals, are currently being associated with phenotypes of clinical relevance, mostly in humans and mice. Notwithstanding, little is known about the extent of CNV that contributes to genetic variation in catt...
ORGANISM(S): Bos taurus 
2010-04-22 | E-GEOD-18174 | biostudies-arrayexpress
TranscriptomicsWidespread, focal copy number variations (CNV) in Trypanosoma cruzi strains
Trypanosoma cruzi is a protozoan parasite and the etiologic agent of Chagas disease, an important public health problem in Latin America. T. cruzi is diploid, almost exclusively asexual, and displays an extraordinarily diverse population structure both genetically and phenotypically. Yet, to date ...
ORGANISM(S): Trypanosoma cruzi 
2011-08-05 | E-GEOD-23576 | biostudies-arrayexpress
TranscriptomicsMaize Inbreds Exhibit High Levels of Copy Number Variation (CNV) and Presence/Absence Variation (PAV) in Genome Content
Following the domestication of maize over the past ,10,000 years, breeders have exploited the extensive genetic diversity of this species to mold its phenotype to meet human needs. The extent of structural variation, including copy number variation (CNV) and presence/absence variation (PAV), which a...
ORGANISM(S): Zea mays 
2009-11-19 | E-GEOD-16938 | biostudies-arrayexpress
TranscriptomicsIntegrated analysis of copy number variation and genome-wide expression profiling in colorectal cancer using macrodissected tissues
The experiment was to elucidate the association between copy number variation (CNV) and gene expression in colorectal cancer (CRC) samples and their corresponding non-cancerous tissues.
ORGANISM(S): Homo sapiens 
2014-06-30 | E-MEXP-3980 | biostudies-arrayexpress
TranscriptomicsThe fine-scale and complex architecture of human copy number variation
Despite considerable excitement over the potential functional significance of copy number variants (CNVs), we still lack knowledge of the fine-scale architecture of the large majority of CNV regions in the human genome. In this study, we used a high-resolution array-based comparative genomic hybridi...
ORGANISM(S): Homo sapiens 
2008-01-23 | E-GEOD-9831 | biostudies-arrayexpress
TranscriptomicsSingle-Stranded Annealing Induced by Re-Initiation of Replication Origins Provides a Novel and Efficient Mechanism for Generating Copy Number Expansion via Non-Allelic Homologous Recombination.
Copy number expansions such as amplifications and duplications contribute to human phenotypic variation, promote molecular diversification during evolution, and drive the initiation and/or progression of various cancers. The mechanisms underlying these copy number changes are still incompletely unde...
ORGANISM(S): Saccharomyces cerevisiae 
2013-01-04 | E-GEOD-41259 | biostudies-arrayexpress
TranscriptomicsCopy number variation profiling of gastric tissues: Cancer Samples vs. Matched Adjacent Noncancerous Samples
Copy number variation profiling of gastric tissues comparing gastric cancer tissues with matched adjacent noncancerous tissues. Goal was to determine the effects of chromosomal imbalances on gene expression and carcinogenesis or progression. 27 pairs of gastric tissues: gastric cancer tissues vs. ma...
ORGANISM(S): Homo sapiens 
2012-05-22 | E-GEOD-33428 | biostudies-arrayexpress
TranscriptomicsDNA copy number variation analysis in hepatoma cell lines
We analyzed specific genes for DNA copy number variation in hepatoma cells and investigated whether these factors are related to liver cancer phenotype. Chromosome 20p, which includes the ligand for Notch pathways, Jagged1, was found to be amplified in several types of hepatoma cells. In conclusion,...
ORGANISM(S): Homo sapiens 
2016-02-04 | E-GEOD-77224 | biostudies-arrayexpress
TranscriptomicsValidation experiment of copy number variations identified by next-generation sequencing in chickens (part 1)
Copy number variation (CNV) is important and widespread in the genome, and is a major cause of disease and phenotypic diversity. Herein, we perform a genome-wide analysis of CNVs in the 12 diversified chicken genomes based on next-generation sequencing. We apply aCGH experiments to confirm our predi...
ORGANISM(S): Gallus gallus 
2015-05-14 | E-GEOD-54117 | biostudies-arrayexpress
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