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UnknownKif11-haploinsufficient oocytes reveal spatially differential requirements for chromosome biorientation.
Not available
S-EPMC12457643 | biostudies-literature
GenomicsKif11-haploinsufficient oocytes reveal spatially differential requirements for chromosome biorientation in the spindle
Kif11-haploinsufficient oocytes reveal spatially differential requirements for chromosome biorientation in the spindle
PRJNA1198919 | ENA
GenomicsShugoshin biases chromosomes for biorientation through condensin recruitment to the pericentromere
To protect against aneuploidy, chromosomes must attach to microtubules from opposite poles (“biorientation”) prior to their segregation during mitosis. Biorientation relies on the correction of erroneous attachments by the aurora B kinase, which destabilizes kinetochore-microtubule attachments that ...
ORGANISM(S): Saccharomyces cerevisiae W303 
2014-01-08 | E-GEOD-53856 | biostudies-arrayexpress
GenomicsA common molecular mechanism underlies the role of Mps1 in chromosome biorientation and the spindle assembly checkpoint
A common molecular mechanism underlies the role of Mps1 in chromosome biorientation and the spindle assembly checkpoint
PRJNA604761 | ENA
TranscriptomicsKif11-haploinsufficient oocytes reveal spatially differential requirements for chromosome biorientation in the spindle
Bipolar spindle assembly and chromosome biorientation are prerequisites for chromosome segregation during cell division. The kinesin motor KIF11 (also widely known as Eg5) drives spindle bipolarization by sliding antiparallel microtubules bidirectionally, elongating a spherical spindle into a bipola...
ORGANISM(S): Mus musculus 
2025-07-01 | GSE284383 | GEO
UnknownBod1, a novel kinetochore protein required for chromosome biorientation.
Not available
S-EPMC2064755 | biostudies-literature
TranscriptomicsExpression profiles of histone point mutants
Accurate chromosome segregation requires that sister kinetochores biorient and attach to microtubules from opposite poles. Kinetochore biorientation relies on the underlying centromeric chromatin, which provides a platform to assemble the kinetochore and to recruit the regulatory factors that ensur...
ORGANISM(S): Saccharomyces cerevisiae 
2013-12-04 | E-GEOD-39903 | biostudies-arrayexpress
UnknownAn engineered minimal chromosomal passenger complex reveals a role for INCENP/Sli15 spindle association in chromosome biorientation.
Not available
S-EPMC5379952 | biostudies-literature
GenomicsA common molecular mechanism underlies the role of Mps1 in chromosome biorientation and the spindle assembly checkpoint
The conserved Mps1 kinase corrects improper kinetochore-microtubule attachments, thereby ensuring chromosome biorientation. Yet, its critical targets in this process remain elusive. Mps1 is also involved in the spindle assembly checkpoint (SAC), the surveillance mechanism halting chromosome segregat...
ORGANISM(S): Saccharomyces cerevisiae 
2020-02-05 | GSE144741 | GEO
UnknownEfficient chromosome biorientation and the tension checkpoint in Saccharomyces cerevisiae both require Bir1.
Not available
S-EPMC2725729 | biostudies-literature
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