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MetabolomicsA metabolite-augmented FIB-4 machine learning panel achieves superior liver fibrosis staging in chronic liver disease

Accurate, non-invasive liver fibrosis detection is essential for chronic liver disease management, particularly with rising metabolic dysfunction-associated liver disease (MASLD) and chronic hepatitis B (CHB). While the Fibrosis-4 (FIB-4) index is widely used, its performance for advanced fibrosi...

2026-03-03 | MTBLS13946 | MetaboLights
MetabolomicsGenome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is a major risk factor leading to chronic liver disease and type 2 diabetes. Here we chart liver metabolic activity and functionality in NAFLD by integrating global transcriptomic data, from human liver biopsies, and metabolic flux data, measured across the ...
2016-12-15 | MTBLS298 | MetaboLights
MetabolomicsSerum metabolomics analysis of patients with chronic obstructive pulmonary disease and 'frequent exacerbator' phenotype

BACKGROUND: Chronic obstructive pulmonary disease (COPD) exacerbations significantly contribute to morbidity and mortality. The complex nature of COPD presents challenges in accurately predicting and understanding frequent exacerbations.

OBJECTIVE: This stu...

2024-02-23 | MTBLS9119 | MetaboLights
MetabolomicsA Cross-Platform Metabolomics Comparison Identifies Serum Metabolite Signatures of Liver Fibrosis Progression in Chronic Hepatitis C Patients
Metabolomics offers new insights into disease mechanisms that is enhanced when adopting orthogonal instrumental platforms to expand metabolome coverage, while also reducing false discoveries by independent replication. Herein, we report the first inter-method comparison when using multisegment injec...
2023-08-22 | MTBLS3111 | MetaboLights
MetabolomicsTissue, urine and serum NMR metabolomics dataset from a 5/6 nephrectomy rat model of chronic kidney disease

Serum, urine and tissue from a rat model of chronic kidney disease (CKD) were analysed using nuclear magnetic resonance (NMR) spectroscopy-based metabolomics methods, and compared with samples from sham operated rats. Both urine and serum were sampled at multiple timepoints, and the results have ...

2020-11-16 | MTBLS2052 | MetaboLights
MetabolomicsChronic inorganic nitrate supplementation does not improve metabolic health and worsens disease progression in mice with diet-induced obesity.
Inorganic nitrate (NO3-) has been proposed to be of therapeutic use as a dietary supplement in obesity and related conditions including the Metabolic Syndrome (MetS), type-II diabetes and metabolic dysfunction associated steatotic liver disease (MASLD). Administration of NO3- to endothelial nitric o...
2025-07-14 | MTBLS9526 | MetaboLights
MetabolomicsRemodeling Lipids in the Transition from Chronic Liver Disease to Hepatocellular Carcinoma (Liver) - part II
Not available
ORGANISM(S): Homo sapiens 
ST001641 | MetabolomicsWorkbench
MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
MetabolomicsEstablishment of a Short-term Mouse Model of Non-alcoholic Fatty Liver Disease with Non-invasive Monitoring

Non-alcoholic fatty liver disease (NAFLD) and its progressive form, non-alcoholic steatohepatitis (NASH), are major chronic liver diseases associated with hepatocellular carcinoma. This study aimed to establish a short-term modified Western diet (mWD)-induced NAFLD model in middle-aged mice and ...

2026-05-31 | MTBLS13096 | MetaboLights
MetabolomicsRemodeling Lipids in the Transition from Chronic Liver Disease to Hepatocellular Carcinoma (Blood) - part I
Not available
ORGANISM(S): Homo sapiens 
ST001640 | MetabolomicsWorkbench
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