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MetabolomicsLong-term low-dose ionizing radiation induced chromosome-aberration-specific metabolic phenotype changes in radiation workers

Long-term low-dose ionizing radiation (LLIR) widely exists in human life and has been confirmed to have potential pathogenic effects on cancer and cardiovascular diseases. However, it is technically and ethically unfeasible to explore LLIR-induced phenotypic changes in the human cohort, leading t...

2022-04-07 | MTBLS3854 | MetaboLights
TranscriptomicsMicroarray analysis of human umbilical vein endothelial cells (HUVECs) chronically irradiated with low dose-rate of ionizing radiation for one, three and six weeks.
To obtain more insight in the molecular effects of chronic low dose irradiation on endothelial cells, HUVEC were irradiated with low-dose rate irradiation (137Cs gamma source; 0, 1.4 and 4.1 mGy/h) for several weeks. At different time points (1, 3 and 6 weeks) cells were harvested for RNA extraction...
ORGANISM(S): Homo sapiens 
2018-02-28 | E-MTAB-6521 | biostudies-arrayexpress
ProteomicsHuman serum proteome of low-dose radiation area
Two sampling areas were focused in this study; Tande tande hamlet as high-level natural background radiation area (HBRA) and Topoyo sub-district as normal level background radiation area (NBRA), which was done under coordination with Local Health Office. The former located in 2° 44’ 38.3’’ south lat...
ORGANISM(S): Homo Sapiens (human) 
2022-05-12 | PXD025946 | JPOST Repository
ProteomicsChronic low-dose ionising radiation rates affect the hippocampal phospho-proteome of synaptogenesis in an ApoE-/--Alzheimer mouse model over 300 days of exposure
Cognitive impairments are an important side effect after radiation exposure. Yet, it comes more and more into scientific focus that ionising radiation can resemble pathologies of neurodegenerative diseases such as Alzheimer´s. Here, we used a multidisciplinary approach to elucidate the effect of chr...
ORGANISM(S): Mus musculus (Mouse) 
2017-07-25 | PXD003969 | Pride
Synapse Proteomics Hippocampus Synaptic plasticity Dendritic spine Phospho-proteomics Creb 
ProteomicsChronic exposure of humans to high level natural background radiation leads to robust expression of protective stress response proteins
Exposures to low doses of ionizing radiation are relevant since most environmental, diagnostic radiology and occupational exposures lie in this region. However, the molecular mechanisms that drive cellular responses at these doses, and the subsequent health outcomes, remain unclear. A local monazite...
ORGANISM(S): Homo sapiens (Human) 
2021-01-28 | PXD022380 | Pride
Chronic low dose radiation Stress response High level natural radiation area (hlnra) Itraq Dose response analysis 
TranscriptomicsRNA-seq of Norwegian spruce embryos exposed to gamma radiation
Conifers such as Picea abies (Norway spruce) are among the most radiosensitive plant species, yet the molecular impact of ionising radiation on their stem cells remains poorly understood. This study examines the transcriptomic response of embryogenic stem cells to gamma radiation, focusing on mechan...
ORGANISM(S): Picea abies 
2025-07-14 | E-MTAB-15297 | biostudies-arrayexpress
TranscriptomicsNon-targeted effects of low dose ionizing radiation act via TGF-beta to promote mammary carcinogenesis
This is a genome-wide approach to identifying genes persistently induced in the mouse mammary gland by acute whole body low dose ionizing radiation (10cGy), 1 and 4 weeks after exposure. Gene expression that is modified under these parameters were compared between Tgfb1 wild type and heterozygote li...
ORGANISM(S): Mus musculus 
2010-03-07 | E-GEOD-18216 | biostudies-arrayexpress
UnknownChronic low-dose γ-irradiation of Drosophila melanogaster larvae induces gene expression changes and enhances locomotive behavior.
Not available
S-EPMC4426922 | biostudies-literature
TranscriptomicsLow- and middle-dose of radiation on hNPC and HUVEC
Many neural progenitor cells present in the fetus, but also in adult brain, which play a major role for the reproduction for healingin regeneration of neuronal cells, when differentiated cells are damaged. However, effects of radiation effect on undifferentiated neural progenitor cells remained uncl...
ORGANISM(S): Homo sapiens 
2015-03-31 | E-GEOD-67309 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human lymphocytes treated with a low dose of ionizing radiation
Effect of low dose ionizing radiation on gene expression profile in human lymphocytes.
ORGANISM(S): Homo sapiens 
2013-05-11 | E-MEXP-2918 | biostudies-arrayexpress
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