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ProteomicsAging-related proteome alterations in B cells may predispose for chronic lymphocytic leukemia - nuclear proteins of elderly B cells
Chronic lymphocytic leukemia (CLL), the most common type of leukemia in adults, is still incurable despite the development of novel therapeutic strategies. This reflects the incomplete understanding of the pathophysiology of this disease. In order to get more detailed insights into CLL development, ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000082941 | MassIVE
TranscriptomicsSNP data from Down syndrome and non-Down syndrome pediatric acute lymphoblastic leukemia cases and controls
SNP profiling can reveal copy number abnormalities and loss of heterozygosity associated with distinct biologic subtypes of acute lymphoblastic leukemia (ALL). We performed SNP profiling of Down syndrome ALL cases and controls to identify unique biologic features of this ALL subgroup. Ficoll-enriche...
ORGANISM(S): Homo sapiens 
2011-07-12 | E-GEOD-21091 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Chronic Lymphocytic Leukemia samples
Microarray technology was used to predict the outcome of Chronic Lymphocytic Leukemia
ORGANISM(S): Homo sapiens 
2007-09-04 | E-TABM-80 | biostudies-arrayexpress
TranscriptomicsEfficacy of retinoids in IKZF1-mutated BCR-ABL1 acute lymphoblastic leukemia
Alterations of IKZF1, encoding the lymphoid transcription factor IKAROS, are a hallmark of high risk acute lymphoblastic leukemia (ALL), however the role of IKZF1 alterations in ALL pathogenesis is poorly understood. Here we show that in mouse models of BCR-ABL1 leukemia, Ikzf1 and Arf alterations s...
ORGANISM(S): Mus musculus 
2015-09-04 | E-GEOD-68391 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human T-cell acute lymphoblastic leukemia, T-cell lymphoblastic lymphoma and B-precursor acute lymphoblastic leukemia samples
T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LL) and are often thought to represent a spectrum of a single disease. The malignant cells in T-ALL and T-LL are morphologically indistinguishable, and they share the expression of common cell surface antigens and cyto...
ORGANISM(S): Homo sapiens 
2007-08-13 | E-GEOD-1577 | biostudies-arrayexpress
TranscriptomicsA Pre-clinical model of induction therapy and relapse in pediatric acute lymphoblastic leukemia
The development of a clinically relevant xenograft model of pediatric acute lymphoblastic leukemia, using a 4-drug treatment regimen designed to mimic pediatric remission induction therapy. Relapse and acquired drug resistance in T-cell acute lymphoblastic leukemia (T-ALL) remains a significant clin...
ORGANISM(S): Homo sapiens 
2013-11-01 | E-MEXP-3916 | biostudies-arrayexpress
TranscriptomicsIllumina and Affymetrix SNP-array data for 2 ETV6/RUNX1-positive Acute Lymphoblastic Leukemia samples and corresponding normal samples
This SuperSeries is composed of the following subset Series: GSE25102: Illumina SNP-array data for 2 ETV6/RUNX1-positive Acute Lymphoblastic Leukemia samples and corresponding normal samples GSE25116: Affymetrix SNP-array data for 2 ETV6/RUNX1-positive Acute Lymphoblastic Leukemia samples and corres...
ORGANISM(S): Homo sapiens 
2012-07-02 | E-GEOD-25117 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of bone marrow samples of 31 children with acute lymphoblastic leukemia to identify changes in gene expression that are associated with the current risk assignment, irrespective of the genetic subtype
We analyzed bone marrow samples of 31 children with acute lymphoblastic leukemia to identify changes in gene expression that are associated with the current risk assignment, irrespective of the genetic subtype
ORGANISM(S): Homo sapiens 
2004-06-28 | E-MEXP-120 | biostudies-arrayexpress
ModelsIGVH mutations in chronic lymphocytic leukemia.
BACKGROUND: Chronic lymphocytic leukemia (CLL) is an incurable malignancy of mature B-lymphocytes, characterized as being a heterogeneous disease with variable clinical manifestation and survival. Mutational statuses of rearranged immunoglobulin heavy chain variable (IGVH) genes has been consider on...
4783 | Cell Collective
TranscriptomicsTranscription profiling of human BCR-ABL1-transformed acute lymphoblastic leukemia cells reveals Activation-induced cytidine deaminase acts as a mutator
The Philadelphia chromosome (Ph) encoding the oncogenic BCR-ABL1 kinase defines a subset of ALL with a particularly unfavorable prognosis. Acute lymphoblastic leukemia (ALL) cells are derived from B cell precursors in most cases and typically carry rearranged immunglobulin heavy chain (IGH) variable...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7182 | biostudies-arrayexpress
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