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ProteomicsChronic pancreatitis vs pancreatic cancer LC-MS
Age-standardized incidence rates for pancreatic cancer (PC) in men have increased by 25% from 1957 to 2011 in Finland. The average age of diagnosis for PC is 69 years in Nordic males, whereas the average age of diagnosis of chronic pancreatitis (CP) is 40-50 years, but the cases overlap in age. By r...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-08-31 | MSV000082883 | MassIVE
ProteomicsProfiling of Kallikrein Proteases and Global Proteome Biology of PDAC, Chronic Pancreatitis and Normal Pancreas
Cell conditioned medium from human pancreatic cancer cell lines MiaPaCa-2, AsPC-1, primary pancreatic cell lines as well as human FFPE tissue samples from pancreatic ductal adenocarcinoma (PDAC), chronic pancreatitis (CP), ampullary cancer, non-malignant adjacent pancreas and normal pancreas were an...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000090255 | MassIVE
TranscriptomicsPancreatic gene expression associated with cerulein induced chronic pancreatitis in mice
A frequently used experimental model of chronic pancreatitis (PC) recapitulating human disease is repeated injection of cerulein to mice. We found that two common substrains of C57BL/6 , C56BL/6J (Jackson) and C57BL/6NHsd (Harlan), exhibit different degree of CP with C57BL/6J beeing more susceptible...
ORGANISM(S): Mus musculus 
2012-10-10 | E-GEOD-41418 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human pancreas from patients with autoimmune pancreatitis and alcohol-induced chronic pancreatitis
Autoimmune pancreatitis (AIP) is a recently identified disease of the pancreas with unknown etiology and antigens. The aim of this study was to determine new target antigens and differentially regulated genes and proteins by means of transcriptomics and proteomics and to validate them in patients wi...
ORGANISM(S): Homo sapiens 
2008-12-31 | E-MEXP-804 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of the pancreas samples from animals showing autoimmune pancreatitis and chronic pancreatitis
Autoimmune pancreatitis (AIP) is a disease with unclear immunologic triggers. This study shows that the pancreatic stellate cells are involved in the regulation of the immune response and can cause autoimmunity when the NF-κB signalling in these cells is disrupted.
ORGANISM(S): Mus musculus 
2022-03-31 | E-MTAB-7274 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of isolated pancreatic stellate cells from mice with autoimmune pancreatitis and chronic pancreatitis
Autoimmune pancreatitis (AIP) is a disease with unclear immunologic triggers. This study shows that the pancreatic stellate cells(PSCs) are involved in the regulation of the immune response and can cause autoimmunity when the NF-κB signalling in these cells is disrupted. The PSCs were isolated from ...
ORGANISM(S): Mus musculus 
2023-06-30 | E-MTAB-7337 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of human pancreas to identify expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis
MicroRNA Expression Patterns to Differentiate Pancreatic Adenocarcinoma From Normal Pancreas and Chronic Pancreatitis
ORGANISM(S): Homo sapiens 
2010-03-11 | E-TABM-664 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human normal pancreas samples, and samples from patients with chronic pancreatitis, pancreatic cancer and metastatic pancreatic cancer
This dataset presents the gene expression profiles of 36 frozen pancreas samples. RNA from 9 normal pancreas samples, 9 samples from patients with chronic pancreatitis, 9 samples from patients with pancreatic cancer and 9 samples from patients with metastatic pancreatic cancer was extracted and hybr...
ORGANISM(S): Homo sapiens 
2006-10-10 | E-EMBL-6 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pancreas from Wistar or WBN/Kob rats to study chronic pancreatitis
Wistar rats, purchased from BRL (Fullinsdorf/BL, Switzerland), and WBN/Kob rats, purchased from SLC Inc. (Shizuoka, Japan), were specific pathogen-free. Rats were housed in groups of maximally 4 instandard cages (1,820 cm2 bottom area) and kept in our animal facility for various time periods between...
ORGANISM(S): Rattus norvegicus 
2009-05-15 | E-MEXP-1704 | biostudies-arrayexpress
MetabolomicsDiagnostic metabolite biomarkers of chronic typhoid carriage
Background: Salmonella Typhi and Salmonella Paratyphi A are the agents of enteric (typhoid) fever; both can establish chronic carriage in the gallbladder. Chronic Salmonella carriers are typically asymptomatic, intermittently shedding bacteria in the feces, and contributing to disease transmission. ...
2018-01-17 | MTBLS579 | MetaboLights
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