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GenomicsEpigenome-wide association study of asthma remission in whole blood and nasal epithelium
Asthma is a chronic respiratory disease which is not curable, yet some patients experience spontaneous remission.In this study, we hypothesized that epigenetic mechanisms may be involved in asthma remission.
EGAS00001004766 | EGA
ProteomicsGu-Ben-Fang-Xiao decoction ameliorates airway remodeling by regulating the PI3K/AKT signaling pathway mediated by RTN4 in a chronic remission asthma murine model
Airway remodeling is a main pathological feature of asthma. The current therapy for asthma is mainly targeted for reducing inflammation, not particularly for airway remodeling. Herein, developing alternative and more effective therapy to attenuate remodeling is worthy of further study. Gu-Ben-Fang-X...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD020711 | Pride
Rtn4 Pi3k/akt pathway Gu-ben-fang-xiao decoction Chronic remission asthma Airway remodeling 
GenomicsGene expression by RNAseq in bronchial biopsies of asthmatics, asthma in remission and healthy subjects
The study focus was differential expression in bronchial biopsies between persistent asthma, asthma in remission and healthy controls using RNAseq.
EGAS00001003735 | EGA
GenomicsEpigenome-wide association study of asthma remission in whole blood and nasal epithelium
Clinical remission (ClinR) was defined as the absence of asthma symptoms and medication for at least 12 months, and complete remission (ComR) was defined as ClinR with normal lung function and absence of airway hyperresponsiveness. We analyzed differential DNA methylation of ClinR and ComR comparing...
EGAD00010002026 | EGA
GenomicsDNA methylation in bronchial biopsies of asthmatics, asthma in remission and healthy subjects
The study focus was differential methylation in bronchial biopsies between persistent asthma, asthma in remission and healthy controls using Illumina 450k arrays.
EGAS00001003739 | EGA
UnknownAsthma remission and its predictors in severe asthma: real-world study from the Korean severe asthma registry.
Not available
S-EPMC12781308 | biostudies-literature
UnknownPathway to Remission in Severe Asthma: Clinical Effectiveness and Key Predictors of Success with Benralizumab Therapy: A Real-Life Study.
Not available
S-EPMC12024904 | biostudies-literature
TranscriptomicsA single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice [scRNA-Seq]
The majority of common chronic human diseases remain incurable, impacting a significant portion of the population and necessitating lifelong treatments that impose a substantial burden on health, the economy, and society. Asthma, the most prevalent respiratory disease, exemplifies this challenge, af...
ORGANISM(S): Homo sapiens 
2024-04-04 | GSE262360 | GEO
TranscriptomicsA single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice [RNA-Seq]
The majority of common chronic human diseases remain incurable, impacting a significant portion of the population and necessitating lifelong treatments that impose a substantial burden on health, the economy, and society. Asthma, the most prevalent respiratory disease, exemplifies this challenge, af...
ORGANISM(S): Mus musculus 
2024-04-04 | GSE262359 | GEO
GenomicsA single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice [scRNA-Seq]
A single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice [scRNA-Seq]
PRJNA1091584 | ENA
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