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MetabolomicsChronic sleep loss sensitizes Drosophila melanogaster to nitrogen stress

Chronic sleep loss profoundly impacts metabolic health and shortens lifespan, but studies of the mechanisms involved have focused largely on acute sleep deprivation. To identify metabolic consequences of chronically reduced sleep, we conducted unbiased metabolomics on heads of three adult Drosoph...

2023-03-18 | MTBLS3318 | MetaboLights
TranscriptomicsTranscription profiling of mouse brain during spontaneous sleep and prolonged wakefulness
These studies address temporal changes in gene expression during spontaneous sleep and extended wakefulness in the mouse cerebral cortex, a neuronal target for processes that control sleep; and the hypothalamus, an important site of sleep regulatory processes. We determined these changes by comparin...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6514 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse brain from 3 inbred strains after sleep deprivation
This SuperSeries is composed of the following subset Series:; GSE9441: The effect of sleep deprivation on gene expression in the brain and the liver of three inbred mouse strains; GSE9442: Molecular correlates of sleep deprivation in the brain of three inbred mouse strains in an around-the-clock exp...
ORGANISM(S): Mus musculus 
2008-06-17 | E-GEOD-9444 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse brain Homer1a-expressing cells after sleep deprivation
To gain insight into the molecular changes of sleep need, this study addresses gene expression changes in a subpopulation of neurons selectively activated by sleep deprivation. Whole brain expression analyses after 6h sleep deprivation clearly indicate that Homer1a is the best index of sleep need, c...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9443 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of whole Drosophila brains fron animals exposed to sleep deprivation
Analysis of brain of Canton-S females deprived of sleep by perturbations during their normal sleep period. Perturbation effect also assessed during their active period to control for its effect during sleep deprivation. Results suggest processes altered during prolonged wakefulness and during sleep.
ORGANISM(S): Drosophila melanogaster 
2007-07-06 | E-GEOD-4174 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse brain and liver from 3 inbred strains - the effect of sleep deprivation on gene expression
These studies adress differential changes in gene expression between 6h sleep deprived and control mice in the brain and the liver. We profiled gene expression in three different inbred strains to understand the influence of genetic background. Experiment Overall Design: Experiments were performed o...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9441 | biostudies-arrayexpress
TranscriptomicsExpression data of sleeping, waking, and sleep deprived adult heterozygous aldh1l1 – eGFP-L10a mice
Transcriptomic studies revealed that hundreds of mRNAs show differential expression in the brains of sleeping versus awake rats, mice, flies, and sparrows. Although these results have offered clues regarding the molecular consequences of sleep and sleep loss, their functional significance thus far h...
ORGANISM(S): Mus musculus 
2015-07-08 | E-GEOD-69079 | biostudies-arrayexpress
no omics definedTranscription profiling of mouse brain response to sleep deprivation
Examination of the effects of increasing durations of sleep deprivation. RNA is collected from two brain regions: cortex and hypothalamus.
ORGANISM(S): Mus musculus 
2011-08-13 | E-TIGR-6 | biostudies-arrayexpress
TranscriptomicsSleep in a dish: key electrophysiological, molecular, and metabolic signatures of sleep and wakefulness revealed in primary cortical cultures
Although at the organismal level sleep is defined as a behavioral state, at the level of the cerebral cortex sleep has a distinct local and use-dependent aspect. This observation raises the question whether sleep is a functional property of a complex brain or occurs at the level of neuronal assembli...
ORGANISM(S): Mus musculus 
2012-08-31 | E-GEOD-33491 | biostudies-arrayexpress
ProteomicsChronic sleep curtailment expediates brain aging by activating the complement and coagulation cascades in mice
Chronic sleep insufficiency is prevalent in modern society and has been associated with age-related neurodegenerative diseases. Loss of sleep accelerates the progression of neurodegeneration in animal models of neurological diseases. Here, we study whether chronic sleep curtailment leads to brain ag...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-10 | PXD060735 | Pride
Chronic sleep deprivation Complement system Brain aging Aging Sleep Proteomics 
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