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TranscriptomicsGenome wide analysis reveals association of a FTO gene variant with epigenetic changes of several genes in human blood
FTO gene variants show the strongest association to obesity so far, but the role of the gene in obesity remains unclear. The FTO protein is a demethylation enzyme, which suggests that the link to obesity could be mediated through epigenetic changes. Herein, we determine the genome wide DNA methylati...
ORGANISM(S): Homo sapiens 
2012-01-10 | E-GEOD-27860 | biostudies-arrayexpress
TranscriptomicsThe effect of GW3965 and dexamethasone on gene expression of rat livers
GLUCOCORTICOIDS are steroid hormones that strongly influence intermediary carbohydrate metabolism by increasing the transcription rate of glucose-6-phosphatase (G6Pase) a key enzyme of gluconeogenesis, and suppress the immune system which makes them one of the most important therapeutic agents in th...
ORGANISM(S): Rattus norvegicus 
2012-04-01 | E-GEOD-29912 | biostudies-arrayexpress
TranscriptomicsCCRF-CEM Prednisolone and MG132 treatments at 4h
Background: The combination of Proteasome inhibitor with Glucocorticoid is one of the most promising antileukemic treatments. Both agents act through pluripotent signal mediators. The two types of agents inhibit key signals that are considered crucial to their effects on malignant cells. Methodology...
ORGANISM(S): Homo sapiens 
2011-05-11 | E-GEOD-29136 | biostudies-arrayexpress
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