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TranscriptomicsTranscription profiling of rat hippocampus treated with kainate to induce seizures - time series
Mesial temporal lobe epilepsy (MTLE) is the most common medically refractory epilepsy syndrome; kainic acid (KA) induced seizures have been studied as a MTLE model as limbic seizures produced by systemic injections of KA result in a distinctive pattern of neurodegeneration in the hippocampus that re...
ORGANISM(S): Rattus norvegicus 
2008-06-11 | E-GEOD-1834 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of hippocampi of rats that were injected with kainic acid at postnatal day (P) 20 to induce early-life seizures and then housed in an enriched environment until P30
Neuropsychiatric consequences of poorly controlled seizures that begin in childhood can be devastating. School failure or behavioral difficulty in a child with epilepsy is common and can become the focus of concern for families. Current antiepileptic drugs compound problems with their CNS side effe...
ORGANISM(S): Rattus norvegicus 
2007-09-14 | E-GEOD-1833 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse P15 hippocampus in kainate-induced seizures
Early childhood convulsions have been correlated with hippocampal neuron loss in patients with intractable temporal lobe epilepsy. Using a "two-hit" rat seizure model, we have shown that animals subjected to kainate (KA)- or hypoxia-induced seizures during early postnatal period showed no cell deat...
ORGANISM(S): Rattus norvegicus 
2008-06-11 | E-GEOD-1831 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of the response of Rattus norvegicus P15 and P30 hippocampus samples treated with kainate
This SuperSeries is composed of the following subset Series:; GSE1831: Temporal analysis of P15 hippocampus in kainate-induced seizures. Koh-2K08NS002068-04; GSE1834: Temporal analysis of hippocampus in kainate-induced seizures. Koh-7K08NS002068-05-3 Experiment Overall Design: Refer to individual ...
ORGANISM(S): Rattus norvegicus 
2007-10-10 | E-GEOD-4236 | biostudies-arrayexpress
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