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TranscriptomicsAmplification of RANK- and c-Met-mediated signaling promotes metastatic colonization
We found that RANKL, expressed by cancer cells or derived from exogenous sources, consistently induced human prostate, breast, kidney, lung and liver cancer cells to colonize or metastasize to bone in an animal model of cancer bone metastasis. RANK-mediated signaling established a premetastatic nich...
ORGANISM(S): Homo sapiens 
2014-02-06 | E-GEOD-48432 | biostudies-arrayexpress
TranscriptomicsNeonatal Skeletal Progenitors
Prospectively isolated and characerized skeletal progenitor lineages 3 repeats per FACS sorted population
ORGANISM(S): Mus musculus 
2015-01-29 | E-GEOD-64447 | biostudies-arrayexpress
TranscriptomicsProlonged Drug Selection of Breast Cancer Cells and Enrichment of Cancer Stem Cell Characteristics.
Background: Cancer stem cells are presumed to have virtually unlimited proliferative and self-renewal abilities and to be highly resistant to chemotherapy, a feature that is associated with overexpression of ATP-binding cassette transporters. We investigated whether prolonged continuous selection of...
ORGANISM(S): Homo sapiens 
2011-09-25 | E-GEOD-24460 | biostudies-arrayexpress
GenomicsGlucocorticoid receptor profiling in IMR90,K562 and U2OS (ChIP-seq)
To identify the sequences responsible for recruitment of Glucocorticoid receptor (GR) to individual loci, we performed ChIP-seq and ChIP-exo that combines chromatin immunoprecipitation with an exonuclease digestion step. We performed these experiments in three cell lines : IMR90 (ATTC:CCL-186), U2O...
ORGANISM(S): Homo sapiens 
2015-02-25 | E-MTAB-2955 | biostudies-arrayexpress
ProteomicsDYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer
Highly malignant pancreatic ductal adenocarcinoma (PDAC) is characterized by an abundant immunosuppressive and fibrotic tumor microenvironment (TME). Future therapeutic attempts therefore demand targeting of both compartments in order to be effective. We show here that Dual Specificity and Tyrosine...
ORGANISM(S): Mus Musculus 
2024-01-02 | MSV000093747 | MassIVE
GenomicsWhole Genome Association Study of Systemic Lupus Erythematosus

The goal of this collaborative study was to identify new genetic risk factors for Systemic Lupus Erythematosus (SLE). To do this we conducted a genome-wide scan by combining the resources and expertise from a number of SLE researchers to establish a large sample set comprising 1311...

phs000122.v1.p1 | EGA
ProteomicsM.musculus - Liver, Protein peptide count (Kislinger,cell,2006)
abundance based on Protein peptide count, Interaction consistency score: 2.8, Coverage: 6
ORGANISM(S): 10090 
2006-00-00 | 768744604 | PAXDB
ProteomicsM.musculus - Heart, Protein peptide count (Kislinger,cell,2006)
abundance based on Protein peptide count, Interaction consistency score: 2.5, Coverage: 6
ORGANISM(S): 10090 
2006-00-00 | 1029310712 | PAXDB
ProteomicsM.musculus - Kidney, Protein peptide count (Kislinger,cell,2006)
abundance based on Protein peptide count, Interaction consistency score: 1.8, Coverage: 6
ORGANISM(S): 10090 
2006-00-00 | 2752498147 | PAXDB
ProteomicsM.musculus - Lung, Protein peptide count (Kislinger,cell,2006)
abundance based on Protein peptide count, Interaction consistency score: 0.6, Coverage: 10
ORGANISM(S): 10090 
2006-00-00 | 3806477322 | PAXDB
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