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TranscriptomicsIn vivo CRISPR screen targeting TSGs in 185-3 MPNST cells
185-3 MPNST cells cells were screened with a CRISPR library against TSGs in vitro and as tumors in Rag1-null and immunocompetent WT C57BL/6 mice
ORGANISM(S): Mus musculus 
2021-10-01 | E-MTAB-10729 | biostudies-arrayexpress
TranscriptomicsPRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies [expression array]
The polycomb repressive complex 2 (PRC2) exerts oncogenic effects in many tumour types1. However, loss-of-function mutations in PRC2 components occur in a subset of haematopoietic malignancies, sug- gesting that this complex plays a dichotomous and poorly understood role in cancer2,3. Here we provid...
ORGANISM(S): Homo sapiens 
2014-10-21 | E-GEOD-62500 | biostudies-arrayexpress
TranscriptomicsSUZ12 and NF1 loss cooperate to enhance Ras transcriptional output and sensitize cancers to epigenetic therapies
The polycomb repressive complex 2 (PRC2) plays an oncogenic role in several cancers. However, loss-of-function mutations in PRC2 components have been detected in a subset of hematopoietic malignancies, suggesting that different epigenetic landscapes are required in different tumor types. In this st...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-52777 | biostudies-arrayexpress
TranscriptomicsDefining key signaling nodes and therapeutic biomarkers in NF1-mutant cancers
The NF1 tumor suppressor encodes a RAS GTPase-Activating Protein (RasGAP). Accordingly, deregulated RAS signaling underlies the pathogenesis of NF1-mutant cancers. However, while various RAS effector pathways have been shown to function in these tumors, it is currently unclear which specific protei...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-57141 | biostudies-arrayexpress
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