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UnknownDiscovery of Novel Nonpeptidic Proteasome Inhibitors Using Covalent Virtual Screening and Biological Evaluation.
Not available
S-EPMC11472392 | biostudies-literature
UnknownA new class of α-ketoamide derivatives with potent anticancer and anti-SARS-CoV-2 activities.
Not available
S-EPMC7873610 | biostudies-literature
UnknownBiological and mutational analyses of CXCR4-antagonist interactions and design of new antagonistic analogs.
Not available
S-EPMC10987480 | biostudies-literature
ProteomicsCXCL12 restricts tumor growth by suppressing the Ras, ERK1/2, c-Myc and the immune checkpoint PDL1 pathways
Cytokines constitute a family of proteins that are secreted by a broad variety of cells and modulate the immune response. CXCL12, along with its receptor CXCR4, are essential players in numerous biological processes. Dysregulation of their function can underlie the mechanisms(s) of several pathologi...
ORGANISM(S): Homo sapiens (Human) 
2024-11-28 | PXD054783 | Pride
Pdl1 Tumor suppression Cxcl12 
UnknownUbiquitin degradation with its substrate, or as a monomer in a ubiquitination-independent mode, provides clues to proteasome regulation.
Not available
S-EPMC2715473 | biostudies-literature
UnknownFAT10 is a proteasomal degradation signal that is itself regulated by ubiquitination.
Not available
S-EPMC3248901 | biostudies-literature
UnknownTackling COVID-19 Using Remdesivir and Favipiravir as Therapeutic Options.
Not available
S-EPMC7675336 | biostudies-literature
UnknownDiscovery of a potent covalent inhibitor that unusually distorts the catalytic dyad of SARS-CoV-2 main protease.
Not available
S-EPMC12548382 | biostudies-literature
UnknownA path toward understanding neurodegeneration.
Not available
S-EPMC6028188 | biostudies-literature
UnknownA short binding site in the KPC1 ubiquitin ligase mediates processing of NF-κB1 p105 to p50: A potential for a tumor-suppressive PROTAC.
Not available
S-EPMC8670467 | biostudies-literature
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