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TranscriptomicsTet1 is a tumor suppressor of hematopoietic maligancy [RNA-Seq]
Loss of Tet1 expression causes global 5mC and 5hmC changes in stem and progenitor cells in mice and enhanced pro-B cell self-renewal, increased DNA damage and B-lymphomageneis. In this study we performed whole transciptome analysis using RNA-sequencing in purified long-term HSCs and MPPs. These resu...
ORGANISM(S): Mus musculus 
2015-04-12 | E-GEOD-65955 | biostudies-arrayexpress
TranscriptomicsTet1 is a tumor suppressor of hematopoietic maligancy [array]
Loss of Tet1 expression causes global 5mC and 5hmC changes in stem and progenitor cells in mice and causes enhanced Pro-B cell self-renewal, increased DNA damage and B-lymphomageneis. In this study we performed microarray analysis of total LSK cells from WT and Tet1 KO mice. These results revealed t...
ORGANISM(S): Mus musculus 
2015-04-12 | E-GEOD-65913 | biostudies-arrayexpress
TranscriptomicsStage-specific control of early B cell development by the transcription factor Ikaros
Ikaros is an essential regulator of lymphopoiesis. Here, we studied the B-cell-specific function of Ikaros by conditional Ikzf1 inactivation in pro-B cells. B-cell development was arrested at an aberrant ‘pro-B’ cell stage characterized by increased cell adhesion and loss of pre-B cell receptor sign...
ORGANISM(S): Mus musculus 
2014-02-09 | E-GEOD-53595 | biostudies-arrayexpress
GenomicsTet1 is a tumor suppressor of hematopoietic malignancy
Epigenetic pathways that regulate DNA methylation and chromatin modifications are frequently found to be dysregulated in human cancers. The TET methylcytosine dioxygenase 1 (TET1) enzyme is an important regulator of hydroxymethylcytosine (5hmC) in embryonic stem cells, neural progenitors,adult cells...
ORGANISM(S): Mus musculus 
2015-04-12 | E-GEOD-65895 | biostudies-arrayexpress
TranscriptomicsMiR-29a maintains mouse hematopoietic stem cell self-renewal by regulating Dnmt3a
Gene expression profiling from fine purified hematopoietic stem and progenitor cells of WT or miR-29a deletion. This anlaysis identified the up- and down-regulated genes from miR-29a deletion, and suggest that cell cycle regulators are significantly changed. The results demonstrate that the HSC lac...
ORGANISM(S): Mus musculus 
2015-03-03 | E-GEOD-58237 | biostudies-arrayexpress
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