Sort   by:  
 Page size 
MetabolomicsA Mammalian Conserved Circular RNA CircLARP2 Regulates Hepatocellular Carcinoma Metastasis and Lipid Metabolism (Part 2)
Not available
ORGANISM(S): Homo sapiens 
ST002395 | MetabolomicsWorkbench
TranscriptomicsTissue-specific circular RNA induction during human fetal development
The pervasive expression of circular RNA from protein coding loci is a recently discovered feature of many eukaryotic gene expression programs. Computational methods to discover and quantify circular RNA are essential to the study of the mechanisms of circular RNA biogenesis and potential functiona...
ORGANISM(S): Homo sapiens 
2015-06-25 | E-GEOD-64283 | biostudies-arrayexpress
TranscriptomicsInduction of circular RNA in fetal heart development recapitulated in in vitro differentiation
We discovered induction of circular RNA in human fetal tissues, including the heart. In this study, we were able to recapitulate this induction by in vitro directed differentiation of hESCs to cardiomyocytes, paving the way for future studies into circular RNA regulation. We harvested hESCs at seque...
ORGANISM(S): Homo sapiens 
2015-06-25 | E-GEOD-64417 | biostudies-arrayexpress
TranscriptomicsAnalysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals
Circular RNAs (circRNAs) are a large class of animal RNAs. To investigate possible circRNA functions, it is important to understand circRNA biogenesis. Besides human Alu repeats, sequence features that promote exon circularization are largely unknown. We experimentally identified new circRNAs in C. ...
ORGANISM(S): Caenorhabditis elegans 
2015-01-06 | E-GEOD-63823 | biostudies-arrayexpress
TranscriptomicsCircular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans.
Circular RNAs (circRNAs) are broadly expressed in eukaryotic cells, but their role in human health and disease remains obscure. Here, we show that circular antisense non-coding RNA in the INK4 locus (circANRIL), which is transcribed at a locus of atherosclerotic cardiovascular disease on chromosome ...
ORGANISM(S): Homo sapiens 
2016-08-22 | E-GEOD-65392 | biostudies-arrayexpress
TranscriptomicsMicroarray expression profile analysis of circular RNAs in human pancreatic ductal adenocarcinoma
To explore the potential involvement of circular RNAs (circRNAs) in pancreatic ductal adenocarcinoma (PDAC) oncogenesis, we conducted circRNA profiling in six pairs of human PDAC and adjacent normal tissue by microarray. Our results showed that clusters of circRNAs were aberrantly expressed in PDAC ...
ORGANISM(S): Homo sapiens 
2015-11-20 | E-GEOD-69362 | biostudies-arrayexpress
ProteomicsA Circular RNA Controls Ribosomal RNA Maturation and Atherosclerosis in Humans
Circular RNAs (circRNAs) are broadly expressed in eukaryotic cells, but their role in human health and disease remains obscure. Here, we show that circular antisense non-coding RNA in the INK4 locus (circANRIL), which is transcribed at a locus of atherosclerotic cardiovascular disease on chromosome ...
ORGANISM(S): Homo sapiens (Human) 
2016-06-10 | PXD001769 | Pride
Circanril rna Pulse-silac Rna pulldowns Lc-ms/ms 
GenomicsCircular RNA characterization in functionally distinct brain regions
Circular RNAs (circRNAs) represent a class of endogenous, non-coding RNAs that are formed when exons back splice to each other and that are both highly conserved and pervasively expressed in the mammalian brain. The goal of this study was thus to systematically identify and characterize circRNA expr...
EGAS00001003128 | EGA
ProteomicsSynthetic circular RNA functions as a miR-21 sponge to suppress gastric carcinoma cell proliferation
MicroRNA (miRNA) sponges containing miRNA complementary binding sites constitute a potentially useful strategy for miRNA-inhibition therapeutics in cancer patients. Recently, naturally occurring circular RNAs (circRNAs) have been revealed to function as efficient microRNA sponges. We hypothesized th...
ORGANISM(S): Homo sapiens (Human) 
2018-10-22 | PXD008584 | Pride
Synthetic circular rna  microrna sponge  microrna loss of function  gastric carcinoma  gene therapy 
MetabolomicsN6-methyladenosine–modified circSLTM inhibits gastric cancer cell proliferation and promotes ferroptosis via interaction with HSPA8

Circular RNAs (circRNAs) are dysregulated in cancers, with N6-methyladenosine (m⁶A)-modified species acting as key regulators of ferroptosis via iron metabolism and lipid peroxidation. This study examines the role of circSLTM (circ-0000605) in gastric cancer (GC). Clinical analyses of GEO data an...

2026-01-16 | MTBLS13702 | MetaboLights
Sort   by:  
 Page size