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TranscriptomicsThe fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma
Expression of the SS18/SYT-SSX fusion protein is believed to underlie the pathogenesis of synovial sarcoma (SS). Recent evidence suggests that deregulation of the Wnt pathway may play an important role in SS but the mechanisms whereby SS18-SSX might affect Wnt signaling remain to be elucidated. Here...
ORGANISM(S): Mus musculus 
2016-02-23 | E-GEOD-78159 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of human pediatric mesenchymal stem cells (hpMSCs) upon expression of EWS-FLI-1
Cancer stem cells (CSCs) display plasticity and self-renewal properties reminiscent of normal tissue stem cells, but the events responsible for their emergence remain obscure. We recently identified CSCs in Ewing sarcoma family tumors (ESFTs) and showed that they retain mesenchymal stem cell (MSC) p...
ORGANISM(S): Homo sapiens 
2011-08-04 | E-GEOD-31215 | biostudies-arrayexpress
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