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TranscriptomicsImmunoregulatory actions of T cell PPAR g at the colonic mucosa
BACKGROUND: Peroxisome proliferator-activated receptor g (PPAR g) is a nuclear receptor whose activation has been shown to modulate macrophage and epithelial cell-mediated inflammation. The objective of this study was to use a systems approach for investigating the mechanism by which the deletion o...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-20523 | biostudies-arrayexpress
TranscriptomicsExpression data from WT and IL-2 secondary CD4 T cell effectors responding towards infuenza A virus infection
How IL-2 produced by secondary CD4 T cell effectors, derived from resting memory cells, impacts memory CD4 T cell function and survival to memory following antigen re-encounter is unknown. We used microarrays to detail the global programme of gene expression underlying differences between WT and IL-...
ORGANISM(S): Mus musculus 
2015-05-14 | E-GEOD-60186 | biostudies-arrayexpress
TranscriptomicsWhole-genome microarray analysis of primary, secondary, tertiary and quaternary memory CD8 T cells
The transcriptome of naive OT-I T cells was compared to memory CD8 T cells after 1, 2, 3, or 4 infection with ovalbumin expressing Listeria monocytogenes (LM-OVA). Naive Thy1.1 OT-I T cells were adoptively transferred into Thy1.2 naive hosts prior to infection with LM-OVA. The resulting memory CD8 T...
ORGANISM(S): Mus musculus 
2010-07-09 | E-GEOD-21360 | biostudies-arrayexpress
TranscriptomicsExpression data from primary and secondary CD4 T cell effectors responding towards influenza A virus infection
How secondary CD4 T cell effectors, derived from resting memory cells, differ from primary cells, derived from naïve precursors, and how such differences impact recall responses to pathogens is unknown. We used microarrays to detail the global programme of gene expression underlying differences betw...
ORGANISM(S): Mus musculus 
2012-08-27 | E-GEOD-40230 | biostudies-arrayexpress
MetabolomicsBiodiversity in marine invertebrate responses to acute warming revealed by a comparative multi-omics approach
Understanding species' responses to environmental change underpins our abilities to make predictions on future biodiversity under any range of scenarios. In spite of the huge biodiversity in most ecosystems, a model species approach is often taken in environmental studies. To date, we still do not k...
2016-06-23 | MTBLS336 | MetaboLights
TranscriptomicsA cell atlas of human thymic development defines T cell repertoire formation
We performed single-cell RNA-sequencing to create a cell census of the human thymus during development, early childhood and adult life. We sampled 15 embryonic and fetal thymi spanning thymic developmental stages between 7 post-conception weeks (PCW) to 17 PCW, and 9 postnatal thymi from paediatric ...
ORGANISM(S): Mus musculus 
2020-02-21 | E-MTAB-8581 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse naive CD4+CD25-CD62Lhi T cells and nTreg cells with Eos knock-down
Eos expression in Treg cells have been documented by several microarrays including ours. We hypothesized that Eos facilitates Foxp3- dependent gene repression in Regulatory T cells. In order to investigate the role of Eos in mediating the Foxp3-dependent gene silencing program, we utilized lentivir...
ORGANISM(S): Mus musculus 
2009-10-16 | E-GEOD-17166 | biostudies-arrayexpress
TranscriptomicsPU.1 regulates T-lineage gene expression and progression via indirect repression during early T-cell development
The Ets family transcription factor PU.1 is essential for the development and maintenance of several hematopoietic lineages. In the thymus, PU.1 is expressed only in the early ETP/DN1, DN2a and DN2b stages of development. While PU.1 deletion in multipotent precursors leads to a complete block in T-c...
ORGANISM(S): Mus musculus 
2015-04-08 | E-GEOD-65344 | biostudies-arrayexpress
TranscriptomicsExpression data from stimulated or unstimulated human CD4+ T cells incubated with edelfosine
The cytotoxic drug edelfosine is a synthetic analog of 2-lysophosphatidylcholine. Edelfosine is incorporated by highly proliferating cells, e.g. activated immune cells. It is unknown if the described mechanisms for edelfosine action attained by in vitro approaches exclusively contribute to the obser...
ORGANISM(S): Homo sapiens 
2014-05-06 | E-GEOD-44392 | biostudies-arrayexpress
TranscriptomicsRegulation of gene expression by RORgamma in Th17 cells
We observed significant growth inhibition of melanoma tumor in ROR?-/- mice, suggesting an important role for the T helper 17 cell (TH17) pathway in tumor immunity. Though RORgamma t (ROR?t) plays a critical role in the development of IL-17-secreting Th17 cells, the role of other genes remained an o...
ORGANISM(S): Mus musculus 
2013-04-17 | E-GEOD-38704 | biostudies-arrayexpress
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