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ProteomicsMetabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target
The genomic landscape of colorectal cancer (CRC) is shaped by inactivating mutations in tumour suppressors such as APC, and oncogenic mutations such as mutant KRAS. Here we used genetically engineered mouse models (GEMMs), and multimodal mass spectrometry-based metabolomics to study the impact of co...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2023-07-18 | MSV000092468 | MassIVE
TranscriptomicsMutual Antagonistic Relationship Between Prostaglandin E2 and Interferon-(gamma): Implications for Rheumatoid Arthritis
PGE2 is a major mediator of inflammation and is present at high concentrations in the synovial fluid of rheumatoid arthritis (RA) patients. PGE2, acting through the EP4 receptor, has both pro- and anti-inflammatory roles in vivo. To shed light on this dual role of PGE2, we investigated its effects ...
ORGANISM(S): Homo sapiens 
2008-05-29 | E-GEOD-11575 | biostudies-arrayexpress
MetabolomicsGNPS - Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target
The genomic landscape of colorectal cancer (CRC) is shaped by inactivating mutations in tumour suppressors such as APC, and oncogenic mutations such as mutant KRAS. Here we used genetically engineered mouse models (GEMMs), and multimodal mass spectrometry-based metabolomics to study the impact of co...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2023-07-18 | MSV000092468 | GNPS
UnknownA multicenter, randomized study of decitabine as epigenetic priming with induction chemotherapy in children with AML.
Not available
S-EPMC5629751 | biostudies-literature
TranscriptomicsExpression profiles from a variety of resting and activated human immune cells
Immune cell-specific expression is one indication of the importance of a gene's role in the immune response. In order to identify such patterns, we set out to broadly profile gene expression in a variety of immune cells. We isolated twelve different types of human leukocytes from peripheral blood an...
ORGANISM(S): Homo sapiens 
2010-07-13 | E-GEOD-22886 | biostudies-arrayexpress
TranscriptomicsGene expression profile of right ventricles from adult wild type and Ezh2-deficient hearts
Adult-onset diseases can be associated with in utero events, but mechanisms for this remain unknown. The polycomb histone methyltransferase, Ezh2, stabilizes transcription by depositing repressive marks during development that persist into adulthood, but its function in postnatal organ homeostasis i...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-34274 | biostudies-arrayexpress
TranscriptomicsTo study glycobiology-related abnormalities in retinal degeneration, an area that is relatively unexplored
Retinal degeneration is the leading cause of irreversible blindness. Retinitis pigmentosa (RP) is a genetically heterogenous group of diseases. In the United States, approximately one in 4000 individuals is affected. RP begins with the loss of night vision due to the loss of rod photoreceptor cel...
ORGANISM(S): Mus musculus 
2011-09-07 | E-GEOD-31990 | biostudies-arrayexpress
ProteomicsHDL proteome remodeling post-stroke
Prospective cohort studies and meta-analyses examining the relationship between HDL-cholesterol (C) and stroke risk are discordant and question the value of HDL-C as a marker for stroke risk prediction. However, the relationship between other metrics of HDL, function and proteome, and stroke remain ...
ORGANISM(S): Homo Sapiens 
2021-01-24 | PXD015001 | panorama
UnknownThe impact of low-mode symmetry on inertial fusion energy output in the burning plasma state.
Not available
S-EPMC10998902 | biostudies-literature
UnknownTMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system.
Not available
S-EPMC9942790 | biostudies-literature
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