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Proteomics,MultiomicsProteomics of EBV-infected lytic and refractory cells
Most humans are infected with Epstein-Barr virus (EBV), a cancer-causing virus. While EBV generally persists silently in B lymphocytes, periodic lytic (re-)activation of latent virus is central to its life cycle and to most EBV-related diseases. However, a substantial fraction of EBV-infected B cell...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079993 | MassIVE
TranscriptomicsStructural basis for retroviral integration into nucleosomes
Retroviral integration is catalyzed by a tetramer of integrase (IN) assembled on viral DNA ends in a stable complex, known as the intasome. How the intasome interfaces with chromosomal DNA, which exists in the form of nucleosomal arrays, is currently unknown. Here we show that the prototype foamy vi...
ORGANISM(S): Homo sapiens 
2015-06-10 | E-GEOD-67730 | biostudies-arrayexpress
ProteomicsInhibition of nuclear PTEN tyrosine phosphorylation enhances glioma radiation sensitivity through attenuated DNA repair
Glioblastoma (GBM) is the most lethal brain tumour that occurs in adults and treatment for GBM has been largely unsuccessful. Ionizing radiation (IR) and chemotherapeutic agents are employed as standard of care treatment for GBM patients and both result in DNA damage. Previous data identified phosph...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-08-07 | MSV000081423 | MassIVE
TranscriptomicsGene expression profiling after induction of WTX in HEK293 cells
WTX encodes a tumor suppressor, frequently inactivated in Wilms tumor, with both plasma membrane and nuclear localization. WTX has been implicated in beta-catenin turnover, but its effect on nuclear proteins is unknown. We report an interaction between WTX and p53, derived from the unexpected observ...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-34715 | biostudies-arrayexpress
TranscriptomicsMultiple genes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression
Chromosomal instability (CIN) is the hallmark of colorectal adenoma to carcinoma progression in 85% of cases, with 20q gain as the most prominent aberration. Yet, the oncogenes at this chromosomal gain are still largely unknown. Here, we aimed to identify oncogenes at 20q involved in colorectal aden...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-8067 | biostudies-arrayexpress
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