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TranscriptomicsStrategies for in vivo screening and mitigation of hepatotoxicity associated with antisense drugs
In this study we tested and modeled the hepatotoxic potential of locked nucleic acid-containing phosphorothioated antisense oligonucleotide (ASOs) gapmers designed to target human BACH1 and PAR-2 transcripts. Using RNA extracted from mouse livers we compared expression profiles of off-target (i.e. g...
ORGANISM(S): Mus musculus 
2017-08-02 | E-MTAB-5180 | biostudies-arrayexpress
TranscriptomicsThe transcriptional response of mouse uterus to estrogen is genetically regulated
The growth and development of the uterus in response to 17β-estradiol (E2) is genetically controlled, with marked variation observed depending on the mouse strain studied. Previous work from our laboratory using inbred mice that are high (C57BL6/J; B6) or low (C3H/HeJ; C3H) responders to E2 has led ...
ORGANISM(S): Mus musculus 
2013-06-11 | E-GEOD-38800 | biostudies-arrayexpress
UnknownGlobal burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
Not available
S-EPMC12535838 | biostudies-literature
UnknownGlobal age-sex-specific all-cause mortality and life expectancy estimates for 204 countries and territories and 660 subnational locations, 1950-2023: a demographic analysis for the Global Burden of Disease Study 2023.
Not available
S-EPMC12535839 | biostudies-literature
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