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UnknownInternal state affects local neuron function in an early sensory processing center to shape olfactory behavior in Drosophila larvae.
Not available
S-EPMC9492728 | biostudies-literature
TranscriptomicsGene expression profiles of Lkb1 WT and KO hematopoietic stem cells (HSCs)
LKB1 encodes a Ser/Thr kinase and acts as an evolutionarily conserved sensor of cellular energy status in eukaryotic cells. LKB1 functions as the major upstream kinase to phosphorylate AMPK and 12 other AMPK-related kinases, which is required for their activation in many cellular contexts. Once acti...
ORGANISM(S): Mus musculus 
2010-12-01 | E-GEOD-24765 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human and mouse dendritic cell subsets
Dendritic cells (DCs) are a complex group of cells which play a critical role in vertebrate immunity. Spleen or lymph node resident DCs are subdivided into conventional DC (cDC) subsets (CD11b and CD8alpha in mouse; BDCA1 and BDCA3 in man) and plasmacytoid DCs (pDCs). It is currently unclear if thes...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9810 | biostudies-arrayexpress
TranscriptomicsThe microRNA miR-124 controls gene expression in the sensory nervous system of Caenorhabditis elegans
We generated animals carrying a genomically integrated mir-124 promoter::gfp transgene and identified mir-124 promoter::GFP labelled cells as a subset of the C. elegans sensory neurons. We used fluorescence activated cell sorting (FACS) to isolate four distinct cell populations: mir-124 expressing (...
ORGANISM(S): Caenorhabditis elegans 
2010-03-22 | E-GEOD-16050 | biostudies-arrayexpress
GenomicsWhole-Genome Sequencing of 128 Ashkenazi Jewish individuals
We sequenced 128 individuals of Ashkenazi Jewish ancestry. All individuals were controls in other studies: (1) Longevity (Gil Atzmon's lab; Albert Einstein College of Medicine), n=74. (2) Parkinson's disease (Lorraine Clark's lab; Columbia University Medical Center), n=54. Whole-genome, high-cover...
EGAS00001000664 | EGA
GenomicsHistone Reader BRWD1 Targets and Restricts Recombination to the Igk Locus
B lymphopoiesis requires that immunoglobulin genes be accessible to RAG1-RAG2 recombinase. However, the RAG proteins bind widely to open chromatin, which suggests that additional mechanisms must restrict RAG-mediated DNA cleavage. Here we show that developmental downregulation of interleukin 7 (IL-7...
ORGANISM(S): Mus musculus 
2015-08-24 | E-GEOD-63302 | biostudies-arrayexpress
UnknownIdentification of candidate genes for familial early-onset essential tremor.
Not available
S-EPMC5070884 | biostudies-literature
UnknownHigh-depth whole genome sequencing of an Ashkenazi Jewish reference panel: enhancing sensitivity, accuracy, and imputation.
Not available
S-EPMC6954822 | biostudies-literature
UnknownGenetic modulation of lipid profiles following lifestyle modification or metformin treatment: the Diabetes Prevention Program.
Not available
S-EPMC3431328 | biostudies-literature
UnknownA Cluster Randomized Trial of Primary Care Practice Redesign to Integrate Behavioral Health for Those Who Need It Most: Patients With Multiple Chronic Conditions.
Not available
S-EPMC10681692 | biostudies-literature
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