Clarke Kai K - OmicsDI

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Metabolomics of the interaction between PPAR-alpha and age in the PPAR-alpha-null mouse (NMR assay)

Regulation between the fed and fasted state in mammals is partially controlled by peroxisome proliferator activated receptor-alpha (PPAR-alpha). Expression of the receptor is high in liver, heart and skeletal muscle, but decreases with age. A combined 1H NMR spectroscopy and GC-MS metabolomic approa...

2018-10-11 | MTBLS261 | MetaboLights

Identification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [beta-catenin organoids]

There is an unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545 a WNT-pathway inhibitor discovered by cell-based screening is a potent and selective chemical probe for the Medi...

ORGANISM(S): Mus musculus

2015-10-26 | E-GEOD-67847 | biostudies-arrayexpress

Identification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [LS-174-T]

ORGANISM(S): Homo sapiens

2015-10-26 | E-GEOD-67846 | biostudies-arrayexpress

Identification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [Colo205]

ORGANISM(S): Homo sapiens

2015-10-26 | E-GEOD-67845 | biostudies-arrayexpress

High-coverage whole-genome sequencing of the expanded 1000 Genomes Project cohort including 602 trios.

Not available

S-EPMC9439720 | biostudies-literature

Effects of empagliflozin on quality of life and healthcare use and costs in chronic kidney disease: a health economic analysis of the EMPA-KIDNEY trial.