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ProteomicsConfirmation of cdk8/19 inhibitor selectivity and activity in colorectal cancer
The Mediator complex is an evolutionarily conserved regulator of gene expression, influencing chromatin structure and RNA polymerase II-mediated transcription. Its activity is modulated by a protein kinase module, which includes cyclin-dependent kinases 8 and 19, that phosphorylate RNA polymerase II...
ORGANISM(S): Homo sapiens (Human) 
2025-07-28 | PXD061476 | Pride
Inhibitor Cdk19 Phosphoproteome Cdk8 Colorectal cancer 
TranscriptomicsAn Invasive Gene Expression Signature in Pancreas Cancer
Gene expression profiling has demonstrated clinical utility as a predictive tool in clinical oncology. We have identified genes associated with invasion of pancreatic cancer, and with potential for identifying early recurrence. We used Affymetrix Human U133 Plus 2.0 microarrays to identify specific ...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-GEOD-22973 | biostudies-arrayexpress
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