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ProteomicsValidation of the expression of clathrin heavy chain muscle isoform including exon 31 at the protein level
A single exon alternative splicing in the CLTC gene determines clathrin coat organization. This event controls plasticity from clathrin-coated pits to plaques, structures that are essential for muscle fiber function and maintenance
ORGANISM(S): Homo sapiens (Human) 
2020-06-19 | PXD018333 | Pride
Human Cltc exon 31 Clathrin heavy chain Differentiation Alternative splicing Clathrin plaques Clathrin coated-pits Muscle 
TranscriptomicsA human genome-wide screen for regulators of clathrin-coated vesicle formation
Clathrin-mediated endocytosis is essential for a wide range of cellular functions. We used a multi- step siRNA-based screening strategy to identify novel regulators of the first step of clathrin- mediated endocytosis, formation of clathrin-coated vesicles (CCVs) at the plasma membrane. A primary gen...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-39954 | biostudies-arrayexpress
ProteomicsClathrin IP_mouse sciatic nerve axons_Roylab_UCSD
Sciatic nerve axon segments from adult mouse were isolated. Following enzymatic digestion, lysate was subjected to incubation with beads conjugated with either clathrin heavy chain antibody or control IgG antibody for clathrin immunoprecipitation. MudPIT analysis was subsequently performed to identi...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-12 | PXD027857 | Pride
Clathrin Axons Sciatic nerves 
ProteomicsBiomolecular condensation orchestrates clathrin-mediated endocytosis in plants
Clathrin-mediated endocytosis is an essential cellular internalisation pathway involving the dynamic assembly of clathrin and accessory proteins to form membrane-bound vesicles. The evolutionarily ancient TSET/TPLATE complex (TPC) plays an essential, but not well-defined role in endocytosis in plant...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-12-07 | PXD045068 | Pride
Ap-ms Arabidopsis Clathrin-mediated endocytosis Tplate complex Ateh1 
ProteomicsUptake of oomycete RXLR effectors into host cells by clathrin-mediated endocytosis
Filamentous (oomycete and fungal) plant pathogens can deliver cytoplasmic effector proteins into host cells to facilitate disease. How RXLR effectors from the potato late blight pathogen Phytophthora infestans enter host cells is unknown. One possible route involves clathrin-mediated endocytosis (CM...
ORGANISM(S): Phytophthora infestans T30-4 Nicotiana benthamiana 
2023-07-20 | PXD040285 | Pride
Oomycete  rxlr effectors  clathrin mediated endocytosis 
ProteomicsProteomic analysis of of the exoproteome of a clathrin mutant
Fungi are the most important plant pathogens on agricultural and horticultural crops. Study of these pathogens remains essential to understand pathogenic process and control plant diseases. In this context, a random insertional mutagenesis strategy, based on the Agrobacterium tumefaciens-mediated tr...
ORGANISM(S): Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea) 
2021-06-11 | PXD023460 | Pride
Phytopathogneic fungus Virulence Quantitative proteome Clathrin mutant 
ProteomicsPhosphorylation of the AP2 μ2 subunit by p70S6 kinase facilitates clathrin-mediated endocytosis.
Clathrin-mediated endocytosis (CME) internalizes cell-surface receptors via clathrin-coated invaginations of the plasma membrane. Both clathrin and endocytic cargo are recruited to these sites by the adaptor protein complex AP2. AP2 cycles between a closed cytoplasmic conformation and an open membra...
ORGANISM(S): Rattus Rattus (black Rat) 
2026-07-31 | PXD080679 | JPOST Repository
TranscriptomicsA human genome-wide screen for regulators of clathrin-coated vesicle formation
Clathrin-mediated endocytosis is essential for a wide range of cellular functions. We used a multi- step siRNA-based screening strategy to identify novel regulators of the first step of clathrin- mediated endocytosis, formation of clathrin-coated vesicles (CCVs) at the plasma membrane. A primary gen...
ORGANISM(S): Homo sapiens 
2012-12-01 | GSE39954 | GEO
ProteomicsMYL3 protects chondrocytes from senescence by inhibiting clathrin-mediated endocytosis and activating of Notch signaling
As the unique cell type in articular cartilage, chondrocyte senescence is a crucial cellular event contributing to osteoarthritis development. Here we show that clathrin-mediated endocytosis and activation of Notch signaling promotes chondrocyte senescence and osteoarthritis development, which is ne...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-07 | PXD044684 | Pride
Osteoarthritis  chondrocyte senescence  clathrin-mediated endocytosis  myosin light chain 3  notch signaling 
GenomicsSDF-1 chemokine signaling modulates the apoptotic responses of clathrin-depleted DT40 cells
The cell line DKO-S is derived form chicken B-Cell DT40 cells where the clathrin heavy-chain has been placed under the control of a tetracycline-regulatable promoter (Tet-Off). The originally derived cell-line DKO-S underwent apoptosis when clathrin expression was repressed. A cell line, DKO-R, deri...
ORGANISM(S): Gallus gallus 
2014-05-07 | GSE57328 | GEO
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