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TranscriptomicsT cell oxygen-sensing proteins establish an immunologically tolerant metastatic niche
Cancer cells must evade immune responses at distant sites to establish metastases. The lung is a frequent site for metastasis. We hypothesized that lung-specific immunoregulatory mechanisms create an immunologically permissive environment for tumor colonization. We found that T cell-intrinsic expres...
ORGANISM(S): Mus musculus 
2016-08-03 | E-GEOD-85131 | biostudies-arrayexpress
TranscriptomicsIonic immune suppression within the tumour microenvironment limits T cell effector function
Tumours progress despite being infiltrated by effector T cells. Tumour necrosis is associated with poor survival in a variety of cancers. Here, we report that that necrosis causes release of an intracellular ion, potassium, into the extracellular fluid of human and mouse tumours. Surprisingly, eleva...
ORGANISM(S): Mus musculus 
2016-08-13 | E-GEOD-84996 | biostudies-arrayexpress
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