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ProteomicsProSeAM SILAC MS screening for METTL9 substrates
Click chemistry based substrates screening for METTL9 in Mettl9 KO MEF cells.
ORGANISM(S): Mus Musculus (mouse) 
2020-11-19 | PXD016823 | JPOST Repository
ProteomicsProSeAM SILAC MS screening for CARNMT1 substrates
Click chemistry based substrates screening for CARNMT1 in Carnmt1 KO HEK293T cells.
ORGANISM(S): Homo Sapiens (human) 
2023-08-24 | PXD037965 | JPOST Repository
GenomicsMaintenance of DNA methylation in embryonic stem cells depends on the histone H3K9 methyltransferases (K9 KO 5hmC-capture-seq)
During mammalian development DNA methylation patterns need to be reset in primordial germ cells (PGC) and preimplantation embryos. However, many retro-transposons and imprinted genes are resistant to such global epigenetic reprogramming via hitherto undefined mechanisms. Here, we report that some of...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-47892 | biostudies-arrayexpress
UnknownSuper-resolution optical DNA Mapping via DNA methyltransferase-directed click chemistry.
Not available
S-EPMC3985630 | biostudies-literature
ProteomicsDrug-target of DNA methyltransferase inhibitors
Malaria eradication requires the development of new drugs to combat drug-resistant parasites. The search for new chemical scaffolds that target novel pathways of the human malaria parasite Plasmodium falciparum is of highest priority. We identified bisbenzylisoquinoline alkaloids isolated from Coccu...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) 
2023-01-01 | PXD036288 | Pride
Plasmodium Click chemistry methyltransferase 
GenomicsEnzymatic or in vivo installation of propargyl groups in combination with click chemistry enables enrichment and detection of methyltransferase target sites in RNA
Enzymatic or in vivo installation of propargyl groups in combination with click chemistry enables enrichment and detection of methyltransferase target sites in RNA
PRJNA430372 | ENA
ProteomicsProSeAM SILAC MS screening for METTL18 substrates
Click chemistry based substrates screening for METTL18 in Mettl18 KO HEK293T cells.
ORGANISM(S): Homo Sapiens (human) 
2022-06-09 | PXD026813 | JPOST Repository
TranscriptomicsMaintenance of DNA methylation in embryonic stem cells depends on the histone H3K9 methyltransferases
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-47894 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of A375 cells treated with tetracycline-based crosslinking probes, with and without competition by parent tetracyclines, to show specific binding of the tetracycline analogs Col-3 and doxycycline on rRNA substructures of the human ribosome
Upon finding that the tetracyclines COL-3 and doxycycline target unique rRNA substructures of the 80S ribosome (E-MTAB-7147), we confirmed these putative ribosomal binding sites by showing that tetracycline-based crosslinking probes are specifically competed from these rRNA structures by their paren...
ORGANISM(S): Homo sapiens 
2018-08-31 | E-MTAB-7161 | biostudies-arrayexpress
OtherEnzymatic or in vivo installation of propargyl groups in combination with click chemistry enables enrichment and detection of methyltransferase target sites in RNA
m6A is the most abundant internal modification in eukaryotic mRNA. It is introduced by METTL3-METTL14 and tunes mRNA metabolism, impacting cell differentiation and development. Precise transcriptome-wide assignment of m6A sites is of utmost importance. However, m6A does not interfere with Watson-Cri...
ORGANISM(S): synthetic construct Homo sapiens 
2018-02-21 | GSE109298 | GEO
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