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Unknown (512486)
Genomics (5225)
Transcriptomics (1779)
Proteomics (1695)
Metabolomics (395)
Clinical (202)
Genomic (172)
Models (49)
Other (38)
Methylation profiling (26)
Multiomics (12)

Organisms

Homo sapiens (1862)
Mus musculus (396)
Rattus norvegicus (100)
Danio rerio (34)
Bos taurus (33)
Gallus gallus (25)
Saccharomyces cerevisiae (17)
Canis lupus familiaris (16)
Mycobacterium tuberculosis (13)
Candida albicans (12)
Sus scrofa (11)
Escherichia coli (10)
Schistosoma mansoni (9)
Arabidopsis thaliana (8)
Macaca mulatta (7)
Oryctolagus cuniculus (6)
Mycobacterium tuberculosis H37Rv (6)
Plasmodium falciparum (6)
Staphylococcus aureus (5)
Severe acute respiratory syndrome coronavirus 2 (4)
Drosophila melanogaster (4)
Macaca fascicularis (4)
Rattus (3)
Mycobacterium avium subsp. paratuberculosis (3)
Schizosaccharomyces pombe (3)
Campylobacter jejuni (3)
Aedes aegypti (3)
H1N1 swine influenza virus (1)
Influenza A virus (A/New Caledonia/20/1999(H1N1)) (1)
Murinae (1)

Organisms

Homo sapiens (2387)
Mus musculus (668)
Rattus norvegicus (52)
Klebsiella pneumoniae (43)
Canis lupus familiaris (28)
Pseudomonas aeruginosa (26)
human gut metagenome (25)
Escherichia coli (24)
Corynebacterium parakroppenstedtii (23)
Acinetobacter baumannii (14)
Mycobacterium tuberculosis (13)
mouse gut metagenome (12)
Staphylococcus aureus (11)
Danio rerio (11)
human metagenome (9)
Sus scrofa (9)
unidentified (7)
Drosophila melanogaster (7)
Helicobacter pylori (7)
Campylobacter jejuni (6)
Bacteria (6)
Plasmodium falciparum (6)
Staphylococcus schleiferi (5)
urine metagenome (5)
Streptococcus agalactiae (5)
Macaca mulatta (5)
Enterococcus faecium (5)
Streptococcus pyogenes (5)
Equus caballus (5)
Corynebacterium pseudokroppenstedtii (4)

Repository

ENA (4781)
biostudies-arrayexpress (1609)
pride (1032)
MetaboLights (389)
geo (353)
EGA (348)
MassIVE (290)
iProX (192)
dbGaP (172)
PeptideAtlas (54)
BioModels (45)
jPOST (45)
PanoramaPublic (29)
GPMDB (12)
PAXDB (12)
EVA (9)
GNPS (6)
Cell Collective (4)
LINCS (4)

Tissue

Cell culture (192)
Blood plasma (102)
Epithelial cell (77)
Brain (66)
Blood serum (57)
Blood (38)
Liver (38)
Heart (36)
Others (30)
Lung (30)
Kidney (23)
Blood cell (20)
Colon (18)
Fibroblast (18)
Stem cell (18)
Primary cell (17)
Skin (16)
Urine (16)
Permanent cell line cell (15)
Macrophage (14)
T cell (14)
B cell (13)
Male Reproductive System (8)
Female Reproductive System (7)
Spleen (3)
Liver (2)
Digestive System (1)
Kidney (1)
Lung (1)
Pancreas (1)

Disease

COVID-19 (15)
Diabetes mellitus (4)
Type 2 diabetes mellitus (2)
Cancer (2)
T-cell acute lymphoblastic leukemia (2)
Ovarian tumor (2)
Normal (2)
Inflammatory bowel disease (1)
Swine influenza (1)
Influenza (1)
XCGD (1)
HPV positive (1)
Multiple myeloma TC3 (1)
HIV-1 seropositive (1)
Fibrosarcoma (1)
Ovarian carcinoma (1)
Burn/trauma (1)
Bladder carcinoma (1)
HIV and HCV coinfected (1)
Rheumatoid Arthritis (1)
Rett syndrome (1)
HIV (1)
Imatinib-resistant CML cell line subclone (1)
Apparently healthy (1)
Hepatoblastoma (1)
Myeloma (1)
Primary tumor (1)
Alpha-1 antitrypsin deficiency (1)
Schistosoma japonicum infection (1)
Critical chronic obstructive pulmonary disease (1)

Technology Type

Illumina HiSeq 2000 (9)
ILLUMINA, Illumina HiSeq 2500 (3)
Illumina HiSeq 2500 (3)
Illumina HiSeq 2000, ILLUMINA (3)
Illumina HiSeq 2500, ILLUMINA (2)
Illumina MiSeq, NextSeq 500, ILLUMINA (1)
Illumina CytoSNP 12 bead array, nanostring (1)
Illumina CytoSNP, Illumina HumanOmni2.5, ILLUMINA, Illumina 450k, Illumina HiSeq 2000 (1)
HiSeq X Ten (ILLUMINA), HiSeq X Ten, ILLUMINA (1)
Illumina HiSeq 2500, Illumina HiSeq 2000 (ILLUMINA), Illumina HiSeq 2000, Illumina (1)
OXFORD_NANOPORE, MinION (1)
ILLUMINA, Illumina HiSeq 4000, Illumina MiSeq (1)
ABI_SOLID, Illumina HiSeq 2000, Illumina 450K, AB 5500xl Genetic Analyzer, AB 5500 Genetic Analyzer, ILLUMINA (1)
Illumina MiSeq, ILLUMINA (1)
HiSeq X Ten, ILLUMINA, Illumina HiSeq 2500 (1)
Illumina HiSeq 4000, ILLUMINA (1)
Illumina_450K, Illumina_HumanHT-12_V4, ILLUMINA, Illumina HiSeq 2000 (1)
CAPILLARY, AB 3730xL Genetic Analyzer (1)
HiSeq X Ten, ILLUMINA (1)
ILLUMINA, Illumina HiSeq 2500, Illumina HiSeq 2000 (1)
ILLUMINA, Illumina MiSeq (1)
Illumina HiSeq 2000, Infinium HumanMethylation450 BeadChip (1)
Illumina MiSeq, Illumina Genome Analyzer IIx (1)
ILLUMINA, Illumina HiSeq 2000 (1)
Illumina Genome Analyzer IIx, Illumina Genome Analyzer II, Affymetrix U219 (1)
Illumina HiSeq 2000, Illumina HiSeq 2000 (ILLUMINA) (1)
Illumina OmniQuad 2.5 - CNVpartition (1)
Illumina HiSeq 2500, Illumina HiSeq 2000 (1)
AB SOLiD 4 System (1)
Illumina SNP array, Illumina HiSeq 2000, Agilent CGH array (1)

Instrument Platform

Illumina NovaSeq 6000 (65)
Illumina HiSeq 4000 (34)
Illumina HiSeq 2500 (27)
NextSeq 500 (24)
Illumina HiSeq 2000 (20)
NextSeq 550 (9)
Illumina NovaSeq X (6)
Agilent High resolution C scanner (4)
Agilent 2100 Bioanalyzer (4)
NextSeq 2000 (4)
DNBSEQ-G400 (4)
DNBSEQ-T7 (4)
Illumina MiSeq (4)
418 [Affymetrix] (3)
Illumina HiSeq 3000 (3)
TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina) (2)
Agilent DNA Microarray Scanner (2)
Illumina HiScanSQ (2)
ScanArray 5000 [PerkinElmer] (2)
DNA Microarray Scanner BA [Agilent Technologies] (2)
Generation III Scanner (2)
NextSeq 1000 (2)
None (2)
NA (2)
HiSeq X Ten (2)
Illumina HiSeq 2000 platform (1)
Illumina DNA Prep sample preparation kits (Illumina Inc., San Diego, CA, USA). Final libraries concentrations and size were assessed with Quant-IT DNA Assay Kit and Agilent 4200 Tapestation System (Agilent Technologies, Milan, Italy), (1)
QIAamp DNA minikit, Qiagen, Germany (1)
DNBelab C Series High-throughput Single-cell RNA Library Preparation Set V3.0 (MGI Tech) (1)
DNBelab C-TaiM droplet generator (MGI Tech) (1)

Publication Date

2025 (419)
2026 (356)
2024 (355)
2022 (295)
2013 (229)
2023 (224)
2014 (224)
2015 (201)
2021 (198)
2010 (175)
2012 (168)
2020 (160)
2011 (159)
2016 (145)
2019 (143)
2018 (118)
2008 (111)
2017 (105)
2009 (78)
2007 (42)
2005 (20)
2006 (18)
2004 (5)
2003 (2)
2027 (2)
2002 (1)

UNIPROT ID/AC

P35568 (4)
P01308 (4)
P06213 (4)
P14672 (3)
P42345 (3)
Q92985 (2)
P62753 (2)
O60343 (2)
Q6R327 (2)
Q8N122 (2)
P01375 (2)
P31751 (2)
P23443 (2)
P29353 (2)
P60484 (2)
P31749 (2)
P01275 (1)
P10515 (1)
P01574 (1)
P01325 (1)
P15208 (1)
P13678 (1)
P63151 (1)
Q07890 (1)
P01008 (1)
P10646 (1)
P12259 (1)
P00451 (1)
P00740 (1)
P00742 (1)

ENSEMBL ID

ENSG00000170477 (47)
ENSG00000229353 (34)
ENSG00000147251 (17)
ENSG00000247315 (12)
ENSG00000204131 (3)
ENSG00000176092 (2)

CHEBI ID

CHEBI:30769 (89)
CHEBI:32816 (58)
CHEBI:17234 (42)
CHEBI:16027 (40)
CHEBI:16761 (25)
CHEBI:36080 (4)
CHEBI:15996 (2)
CHEBI:17552 (2)
180533 (1)
5383 (1)
CHEBI:15552 (1)
CHEBI:16618 (1)
CHEBI:18357 (1)
CHEBI:16905 (1)
CHEBI:422 (1)
CHEBI:15946 (1)
CHEBI:30744 (1)
CHEBI:4167 (1)
CHEBI:44897 (1)
CHEBI:4170 (1)
CHEBI:15346 (1)
CHEBI:15422 (1)
CHEBI:16908 (1)
CHEBI:15846 (1)
CHEBI:16526 (1)
CHEBI:28602 (1)
CHEBI:15713 (1)
CHEBI:16001 (1)
CHEBI:17794 (1)
CHEBI:17835 (1)

Metabolite Name

Creatine (73)
Taurine (71)
Creatinine (65)
Hypoxanthine (60)
Uridine (59)
Inosine (56)
Ornithine (54)
Glycine (52)
Adenosine (52)
Choline (51)
Guanosine (51)
Citrulline (50)
Xanthine (49)
Adenine (48)
Uracil (44)
Glutamine (44)
Cytidine (44)
Pyroglutamic acid (43)
L-Histidine (42)
Citric acid (42)
Alanine (42)
L-Tyrosine (42)
Leucine (41)
Betaine (41)
Lysine (41)
Phenylalanine (41)
L-Phenylalanine (40)
Valine (39)
L-Proline (39)
Tyrosine (39)

First Public Date

2025 (659)
2026 (608)
2024 (577)
2014 (545)
2023 (426)
2022 (418)
2021 (330)
2020 (295)
2019 (251)
2018 (169)
2015 (163)
2017 (144)
2016 (114)
2013 (82)

Modelling Approach

Ordinary differential equation model (29)
Machine learning (2)
Other (2)
Population model (2)
Constraint-based model (2)
Fuzzy logic model (1)
Biochemical network (1)
Mathematical model (1)
Boolean model (1)
Differential equation model (1)

Study status

Recruiting (62)
Completed (61)
Not yet recruiting (35)
Not provided (15)
Active, not recruiting (12)
Terminated (11)
Withdrawn (5)
Enrolling by invitation (1)

Lab affiliation

Systems Biology Laboratory, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency (8)
Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Division of Infection Medicine, Lund, Sweden (7)
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences (7)
Baylor College of Medicine (6)
Head of System Biology Lab. at Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency (6)
Clinical Division of Fish Medicine, University of Veterinary Medicine, Vienna, Austria (5)
Research Unit for Molecular Medicine, Department of clinical Medicine, Aarhus University, Aarhus, Denmark (5)
Department of Clinical Science, Faculty of Medicine, University of Bergen, Norway (4)
Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency (4)
Lab of Proteome Research, Department of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia (4)
State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China (4)
Systems Inflammation group, Centre of Molecular Inflammation Research (CEMIR), and Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Norway (4)
Thoracic Oncology Molecular Medicine Program Moffitt Cancer Center Tampa, FL, USA (4)
Chair of Proteomics and Bioanalytics, Technische Universität München, Germany (3)
Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany (3)
Department of Experimental and Clinical Medicine, University of Catanzaro (3)
Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel (3)
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA (3)
Department of Molecular & Clinical Cancer Medicine Institute of Systems, Molecular & Integrative Biology University of Liverpool (3)
Department of Molecular Biology and Genetics, Lab of Proteome Research, Federal Research and Clinical Centre of Physical-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow, 119992, Russia (3)
Executive Science Officer, BioFrontiers InstituteDistinguished ProfessorProfessor, Howard Hughes Medical Institute MOLECULAR CELLULAR AND DEVELOPMENTAL BIOLOGY CU DENVER SCHOOL OF MEDICINE (3)
Head of System Biology Lab. at Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Russia (3)
III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (3)
Institute of Clinical Medicine in National Yang-Ming Chiao Tung University, Taiwan (Muh-Hwa Yang Lab) (3)
Manchester Academic Health Science Centre, Division of Cell Matrix Biology & Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester, UK (3)
Penn State College of Medicine, Department of Medicine, Penn State Cancer Institute. (3)
Research Unit for Molecular Medicine, Department of Clinical Medicine, Aarhus University, Denmark (3)
School of Biomedical Sciences and Department of Pathology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China (3)
System Biology Lab. at Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency (3)
1 Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and HUS Helsinki University Hospital, P.O.Box 263, FI-00029 HUS, Helsinki, Finland 2 Department of Biosciences and Nutrition, Karolinska Institutet, SE-171 76, Stockholm, Sweden. 3 Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland. (2)

Keyword

Colorectal (7)
Metastatic (7)
Bevacizumab (6)
Trifluridine (5)
S95005 (4)
Nivolumab (4)
Capecitabine (4)
Irinotecan (4)
Chemotherapy (4)
Lonsurf (3)
Colorectal cancer screening (3)
Oxaliplatin (3)
Futuximab/modotuximab (2)
Efatutazone (2)
Trifluridine/tipiracil (2)
Anti-EGFR (2)
Trastuzumab deruxtecan (2)
Pembrolizumab (2)
Rectum (2)
Colon (2)
Cetuximab (2)
Javanica oil emulsion injection (1)
Hypnose (1)
Representations (1)
Yttrium-90 radioembolization (1)
Early access (1)
SOMATULINE AUTOGEL 120 MG INJ SOL 1X0.5ML/120MG (1)
Russia (1)
Trifluridine + tipiracil hydrochloride (S 95005/TAS-102) (1)
Safety Lead-In part (1)

IsPrivate

False (45)

Model Flag

Non Kinetic (2)

Submitter Keywords

Immuno-oncology (3)
Manuscript Accepted (2)
Not Peer Reviewed (2)
COVID-19 (2)
Machine Learning Model (1)
FROG (1)

Classification

bacteria (284)
viruses (21)
protozoa (12)
fungi (9)
helminths (1)

Modification

2x(15)N labeled L-lysine (3)
Not available (3)
4x(15)N labeled L-arginine (2)
N6-dimethyl-L-lysine (2)
-17.026549 (1)
-18.010565 (1)
15.994915 (1)
3'' (1)
4-tetrahydrothiazine-3-carboxylic acid (1)
42.010565 (1)
57.021464 (1)
N6 (1)

Study type

Transcription profiling by array (1066)
RNA-seq of coding RNA (222)
Comparative genomic hybridization by array (41)
Unknown experiment type (34)
Methylation profiling by array (32)
Proteomic profiling by array (24)
RNA-seq of non coding RNA (24)
ChIP-seq (23)
DNA-seq (18)
RNA-seq of coding RNA from single cells (16)
Genotyping by array (13)
RNA-seq of total RNA (12)
Other (11)
Transcription profiling by RT-PCR (10)
Methylation profiling by high throughput sequencing (8)
ChIP-chip by tiling array (7)
Human - High-throughput sequencing (6)
MicroRNA profiling by array (6)
Transcription profiling by tiling array (4)
Animal - One-color microarray (3)
Animal - High-throughput sequencing (3)
MicroRNA profiling by high throughput sequencing (3)
One-color microarray (2)
Human - One-color microarray (2)
ChIP-chip by array (2)
Antigen profiling (2)
Null (1)
MeDIP-seq (1)
Human - Methylation microarray (1)
Human - Single-cell sequencing (1)

Release Date

2022 (68543)
2025 (65476)
2023 (60841)
2021 (59397)
2024 (52219)
2020 (43164)
2019 (31009)
2018 (25555)
2017 (20932)
2016 (18006)
2015 (15613)
2014 (12589)
2026 (9339)
2013 (7574)
2012 (5750)
2011 (4852)
2010 (3663)
2009 (2703)
2008 (1952)
2007 (1116)
2006 (872)
2005 (777)
2004 (491)
2003 (401)
2002 (330)
2001 (304)
2000 (264)
1999 (190)
1998 (114)
1997 (24)

Location

China (54)
United States (45)
Australia (25)
France (17)
Japan (14)
United Kingdom (12)
Italy (12)
Spain (10)
Canada (10)
Germany (9)
Poland (8)
Belgium (8)
Denmark (6)
Russia (5)
Brazil (5)
Taiwan (4)
Ukraine (4)
South Korea (4)
Czechia (4)
Switzerland (4)
Sweden (4)
India (3)
Slovakia (3)
Turkey (3)
Portugal (3)
Bulgaria (3)
Argentina (3)
Hungary (3)
Netherlands (3)
Finland (2)

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Clinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats.

OBJECTIVE: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

METHOD...

2024-03-25 | MTBLS5667 | MetaboLights

Metagenomics and Metabolomics Integrated to Explore the Protective Mechanisms of Mongolian Medicine Zadi-5 in Myocardial Ischemic Model Rats

Myocardial ischemia(MI) is a pathological state of abnormal energy metabolism due to insufficient blood and oxygen supply to the coronary arteries. The 'gut-heart axis' theory plays an important role in myocardial ischemia occurrence, mechanism, prevention, and cure. Traditional Mongolian medicin...

2026-01-27 | MTBLS13780 | MetaboLights

Identification of chemotypes in bitter melon by metabolomics: a plant with potential benefit for management of diabetes in traditional Chinese medicine

INTRODUCTION: Bitter melon (Momordica charantia, Cucurbitaceae) is a popular edible medicinal plant, which has been used as a botanical dietary supplement for the treatment of diabetes and obesity in Chinese folk medicine. Previously, our team has proved that cucurbitanes triterp...

2019-10-24 | MTBLS701 | MetaboLights

Metabolomics study of COVID-19 patients in four different clinical stages

SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is the coronavirus strain causing the respiratory pandemic COVID-19 (coronavirus disease 2019). To understand the pathobiology of SARS-CoV-2 in humans it is necessary to unravel the metabolic changes that are produced in the individuals...

2025-01-24 | MTBLS3800 | MetaboLights

Expanding the clinical use of DBS: through a metabolomic and a lipidomic evaluation

Personalized medicine aims to tailor healthcare to individual characteristics, relying on precise biological data and patient monitoring. Metabolomics and lipidomics play a key role in this approach, providing real-time insights into metabolic states and enabling accurate diagnosis and treatment ...

2026-02-25 | MTBLS13382 | MetaboLights

Metabolomic signatures discriminate horses with clinical signs of atypical myopathy from healthy co-grazing horses

Atypical myopathy (AM) is a severe rhabdomyolysis syndrome that occurs in grazing horses. Despite the presence of toxins in their blood, all horses from the same pasture are not prone to display clinical signs of AM. The objective of this study was to compare the blood metabolomic profiles of horses...

2021-08-31 | MTBLS2579 | MetaboLights

Linking gastrointestinal microbiota and metabolome dynamics to clinical outcomes in pediatric hematopoietic stem cell transplantation

BACKGROUND: Hematopoietic stem cell transplantation is a curative procedure for a variety of conditions. Despite major advances, a plethora of adverse clinical outcomes can develop post-transplantation including graft-versus-host disease and infections, which remain the major cau...

2022-05-11 | MTBLS4065 | MetaboLights

Mongolian medicine Wulanwendusu-11 ameliorates myocardial ischemia-reperfusion injury in association with the modulation of intestinal microbiota and associated metabolic pathways

Abstract

Objective: Wulanwendusu-11 (WLWDS-11), a traditional Mongolian medicinal formula, is commonly used for the treatment of Cardiovascular diseases. However, its therapeutic material basis and in vivo metabolic profile in the context of chronic myocardial ischemia-reperfusion injury (M...

2025-11-22 | MTBLS13370 | MetaboLights

Dynamic Changes and Clinical Significance of Gut Microbiota and Serum Metabolites in Breast Cancer Onset, Progression and Chemotherapy Intervention

Background: Breast cancer progression and treatment are increasingly linked to systemic metabolic and microbial alterations. Previous studies have identified distinct gut microbiome profiles and serum metabolite shifts in breast cancer patients compared to healthy individuals, yet longitudi...

2026-05-08 | MTBLS13634 | MetaboLights

Adjunctive ibuprofen in pre-extensively drug-resistant and extensively drug-resistant tuberculosis: a Phase IIA open-label pilot clinical trial

Drug-resistant tuberculosis (TB) remains a major global health challenge. Host-directed therapies (HDTs) aim to limit tissue damage, shorten treatment, and improve outcomes by modulating immune responses. We evaluated the safety and potential efficacy of adjunctive ibuprofen an inexpens...

2026-05-28 | MTBLS13376 | MetaboLights