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MetabolomicsAdjunctive ibuprofen in pre-extensively drug-resistant and extensively drug-resistant tuberculosis: a Phase IIA open-label pilot clinical trial

Drug-resistant tuberculosis (TB) remains a major global health challenge. Host-directed therapies (HDTs) aim to limit tissue damage, shorten treatment, and improve outcomes by modulating immune responses. We evaluated the safety and potential efficacy of adjunctive ibuprofen an inexpens...

2026-05-28 | MTBLS13376 | MetaboLights
MetabolomicsNR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson's disease

Nicotinamide adenine dinucleotide (NAD) replenishment therapy using nicotinamide riboside (NR) shows promise for Parkinson’s disease (PD) and other neurodegenerative disorders. However, the optimal dose of NR remains unknown, and doses exceeding 2000 mg daily have not been tested in humans. To ev...

2025-04-09 | MTBLS8812 | MetaboLights
MetabolomicsNeuromodulator Metabolites of Dietary Salt Effects on Blood Pressure in Human Urine from DASH2 Clinical Trial (part IX)
Not available
ORGANISM(S): Homo sapiens 
ST000636 | MetabolomicsWorkbench
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
MetabolomicsAmino Acid Metabolites of Dietary Salt Effects on Blood Pressure in Human Urine from DASH2 Clinical Trial (part VIII)
Not available
ORGANISM(S): Homo sapiens 
ST000635 | MetabolomicsWorkbench
MetabolomicsTCA Cycle Metabolites of Dietary Salt Effects on Blood Pressure in Human Urine from DASH2 Clinical Trial (part VII)
Not available
ORGANISM(S): Homo sapiens 
ST000634 | MetabolomicsWorkbench
MetabolomicsComparison of lipidome profiles of Caenorhabditis elegans—results from an inter-laboratory ring trial

Introduction

Lipidomic profiling allows 100s if not 1000s of lipids in a sample to be detected and quantified. Modern lipidomics techniques are ultra-sensitive assays that enable the discovery of novel biomarkers in a variety of fields and provide new insight in mechanistic investigations. D...
2022-02-21 | MTBLS2016 | MetaboLights
MetabolomicsTargeting the gut-lung axis by synbiotic feeding to infants in a randomized controlled trial

Synbiotics may modulate gut microbiota and prevent infections. In a randomized controlled trial (NCT01625273) infants weaned from breast milk were fed formula with prebiotics (fructo- and galactooligosaccharides) or the same prebiotic formula with Lactobacillus paracasei ssp. paracasei s...

2022-11-24 | MTBLS2438 | MetaboLights
MetabolomicsNeuromodulator Metabolites of Dietary Salt Effects on Blood Pressure in Human Urine from 20 Participants of the DASH2 Clinical Trial (part III)
Not available
ORGANISM(S): Homo sapiens 
ST000630 | MetabolomicsWorkbench
MetabolomicsTCA Cycle Metabolites of Dietary Salt Effects on Blood Pressure in Human Urine from 20 Participants of the DASH2 Clinical Trial (part I)
Not available
ORGANISM(S): Homo sapiens 
ST000628 | MetabolomicsWorkbench
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