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GenomicsCLN7 suppression induces apoptosis via mTOR-regulated and chaperone-mediated autophagy in myeloid leukemia cells
CLN7 suppression induces apoptosis via mTOR-regulated and chaperone-mediated autophagy in myeloid leukemia cells
PRJNA1441561 | ENA
TranscriptomicsCLN7 suppression induces apoptosis via mTOR-regulated and chaperone-mediated autophagy in myeloid leukemia cells
Refractory disease and relapse continue to impede effective treatment of myeloid leukemia, despite substantial progress in therapeutic approaches. Emerging evidence implicates lysosomal ion channels in the regulation of cell death pathways, highlighting these channels as viable targets for therapeut...
ORGANISM(S): Homo sapiens 
2026-06-20 | GSE325745 | GEO
UnknownCLN7 is an organellar chloride channel regulating lysosomal function.
Not available
S-EPMC8673761 | biostudies-literature
UnknownAberrant upregulation of the glycolytic enzyme PFKFB3 in CLN7 neuronal ceroid lipofuscinosis.
Not available
S-EPMC8795187 | biostudies-literature
UnknownCLN7/MFSD8 may be an important factor for SARS-CoV-2 cell entry.
Not available
S-EPMC9444308 | biostudies-literature
UnknownLoss of CLN7 results in depletion of soluble lysosomal proteins and impaired mTOR reactivation.
Not available
S-EPMC5932567 | biostudies-literature
UnknownDiscovery of a CLN7 model of Batten disease in non-human primates.
Not available
S-EPMC6200145 | biostudies-literature
UnknownRepurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype.
Not available
S-EPMC8495452 | biostudies-literature
UnknownCLN7 protein functions at the interface between endolysosomes and stress granules to promote cell survival.
Not available
S-EPMC12579238 | biostudies-literature
UnknownExpression and lysosomal targeting of CLN7, a major facilitator superfamily transporter associated with variant late-infantile neuronal ceroid lipofuscinosis.
Not available
S-EPMC3298853 | biostudies-literature
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