Clonal selection

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UNIPROT ID/AC

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9606.ENSP00000233596 (1)
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CHEBI ID

CHEBI:18237 (3)
CHEBI:22653 (3)
CHEBI:18186 (3)
CHEBI:28300 (3)
CHEBI:15741 (3)
CHEBI:16449 (3)
CHEBI:78320 (3)
CHEBI:68566 (2)
CHEBI:25351 (2)
CHEBI:74168 (2)
CHEBI:26271 (2)
CHEBI:17858 (2)
CHEBI:17126 (2)
CHEBI:22660 (2)
CHEBI:26986 (2)
CHEBI:24898 (2)
CHEBI:25017 (2)
CHEBI:30794 (2)
CHEBI:6650 (2)
CHEBI:28044 (2)
CHEBI:16865 (2)
CHEBI:27266 (2)
CHEBI:17750 (2)
CHEBI:17151 (2)
CHEBI:18211 (2)
CHEBI:15891 (2)
CHEBI:17084 (2)
CHEBI:18300 (2)
CHEBI:32806 (2)
CHEBI:16704 (2)

Metabolite Name

Hydroxy-proline (2)
Hydroxyglutaric acid (2)
Methylglutaric acid (2)
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IsPrivate

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Classification

bacteria (6)
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Modelling Approach

Agent-based model (1)

Study type

Transcription profiling by array (154)
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Human - High-throughput sequencing (3)
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Other (2)
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Release Date

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Lab affiliation

Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands (3)
Division of Genetic and Genomic Medicine, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, USA (2)
Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands (1)
Centre for Proteome Research University of Liverpool Liverpool L69 7ZB (1)
Department of Aquatic Ecology, Eawag, Überlandstrasse 133, 8600 Dübendorf, Switzerland (1)
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (1)
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel (1)
Division of Molecular Hematology, Department of Laboratory Medicine, Lund University (1)
Faculty of Science, Engineering & Medicine, School of Life Sciences, University of Sussex, United Kingdom (1)
German Cancer Research Center, Heidelberg (1)
Gregor Mendel Institute of the Austrian Academy of Sciences (1)
ITQB NOVA (1)
King’s College London Faculty of Life Sciences & Medicine Room 3.10 Franklin-Wilkins Building 150 Stamford Street, London SE1 9NH United Kingdom (1)
MED—Mediterranean Institute for Agriculture, Environment and Development & CHANGE—Global Change and Sustainability Institute, School of Science and Technology, University of Évora, Pólo da Mitra, Ap. 94, 7002-554 Évora, Portugal (1)
Max Planck Institute for Molecular Biomedicine Bioanalytical Mass Spectrometry Röntgenstr. 20 48159 Münster Germany (1)
McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 USA (1)
Molekulare Genomanalyse (B050) Deutsches Krebsforschungszentrum Im Neuenheimer Feld 580 69120 Heidelberg Germany (1)
National Institute for Biological Standards and Control (1)
OncoProteomics Laboratory, Dept of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands (1)
Peter MacCallum Cancer Centre, Melbourne, Australia Department of Anatomy and Physiology, The University of Melbourne, Melbourne, VIC, Australia (1)
The Gade Research Group for Infection and Immunity, Department of Clinical Science, University of Bergen, Norway (1)
Wellcome Trust Sanger Institute (1)

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Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution

In this study, using a murine model of Ph+ acute lymphoblastic leukemia (Ph+ ALL), a combined pharmacological profile and drug selection experimental approach identified distinct stages of tumor clonal evolution with vulnerabilities to sets of small molecules. Through genotypic, phenotypic, signalin...

ORGANISM(S): Mus musculus

2016-04-05 | E-GEOD-72910 | biostudies-arrayexpress

Clonal Selection Drives Genetic Divergence of Metastatic Medulloblastoma

This SuperSeries is composed of the following subset Series: GSE34280: Clonal Selection Drives Genetic Divergence of Metastatic Medulloblastoma [Affymetrix SNP6 Arrays] GSE34355: Clonal Selection Drives Genetic Divergence of Metastatic Medulloblastoma [Illumina Infinium HumanMethylation27 Beadchip v...

ORGANISM(S): Homo sapiens

2011-12-13 | E-GEOD-34356 | biostudies-arrayexpress

Differential Gene Expression and Clonal Selection during Cellular Transformation Induced by Adhesion Deprivation

This SuperSeries is composed of the following subset Series: GSE24877: Differential Gene Expression and Clonal Selection during Cellular Transformation Induced by Adhesion Deprivation (A16 vs NA16) GSE24878: Differential Gene Expression and Clonal Selection during Cellular Transformation Induced by ...

ORGANISM(S): Rattus norvegicus

2010-11-14 | E-GEOD-24893 | biostudies-arrayexpress

Cardiac precursor differentiation from hESCs by lentiviral promoter drug selection

Several of the essential core transcriptional control elements in human embryonic stem cells (ESCs) have been identified, but the production and function of alternative isoforms in self-renewal, pluripotency and tissue lineage specification remain largely unknown. We have modified the H9 ESC line to...

ORGANISM(S): Homo sapiens

2008-10-24 | E-GEOD-13297 | biostudies-arrayexpress

Tissue-specific clonal selection and differentiation of CD4⁺ T cells during infection.

PRJNA1405698 | ENA

Cell of origin epigenetic priming determines susceptibility to Tet2 mutation

Hematopoietic stem cell (HSC) mutations can result in clonal hematopoiesis (CH) with heterogeneous clinical outcomes. Here, we investigated how the cell state preceding Tet2 mutation impacts the pre-malignant phenotype. Using an inducible system for clonal analysis of myeloid progenitors...

2024-04-30 | MTBLS9914 | MetaboLights

Phosphoproteomics measurement of clonal endocrine therapy sensitive and resistant breast cancer populations

Around two thirds of breast tumors are characterized by the expression of estrogen receptor α and are therapeutically treated by blocking estrogen signaling. First line endocrine therapeutics are Tamoxifen which displaces estrogen form its receptor preventing receptor activation and aromatase inhibi...

ORGANISM(S): Homo sapiens (Human)

2024-01-26 | PXD040478 | Pride

Dynamic Regulation of Tfh Clonal Selection During the Germinal Center Reaction

PRJNA613275 | ENA

Clonal Selection Drives Genetic Divergence of Metastatic Medulloblastoma [Affymetrix SNP6 Arrays]

Medulloblastoma, the most common malignant pediatric brain tumour, disseminates by shedding cells into the cerebrospinal fluid, which then re-implant to cover the surface of the brain and spinal cord. Metastases are a very poor prognostic sign at presentation and are usually lethal at recurrence. ...

ORGANISM(S): Homo sapiens

2011-12-09 | E-GEOD-34280 | biostudies-arrayexpress

Genomic diversity of a pneumococcal clonal complex, 199

Comparative genomic hybridisation of Streptococcus pneumoniae isolates from a single clonal complex, in order to determine genomic diversity. Isolates were selected from a range of tissue types and serotypes in order to cover the full diversity of the clone, and also in order to try and identify tis...

ORGANISM(S): Streptococcus pneumoniae

2010-09-07 | E-GEOD-23992 | biostudies-arrayexpress

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