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UnknownSignaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages.
Not available
S-EPMC8784330 | biostudies-literature
UnknownChemical variability for authenticated and commercial <i>Artemisia absinthium</i> L. essential oils with thujones on tephritid fruit flies: Mediterranean fruit fly <i>Ceratitis capitata</i> (Wiedemann) and Caribbean fruit fly <i>Anastrepha suspensa</i> (Loew).
Not available
S-EPMC12675350 | biostudies-literature
TranscriptomicsMicroRNA-182-5p targets a network of genes involved in DNA repair
MicroRNAs are non-coding regulators of gene expression, which act by repressing protein translation and/or degrading mRNA. Many have been shown to drive tumorigenesis in cancer, but functional studies to understand their mode of action are typically limited to single target genes. In this study we u...
ORGANISM(S): Homo sapiens 
2013-01-29 | E-GEOD-38593 | biostudies-arrayexpress
TranscriptomicsImperfect centered miRNA binding sites are common and can mediate functional repression of target mRNAs [sequencing]
Whole transcriptome identification of direct targets identify a new class of miRNA::mRNA interactions. This is a qualitative experiment to check transcript structure of mRNAs that bind to miR-17-5p. HEK293T cells were transfected with biotinylated miRNAs. The miRNAs and target mRNA were pulled down ...
ORGANISM(S): Homo sapiens 
2014-02-14 | E-GEOD-55058 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of gene expression and intron retention during development in a U12-type splicing-deficient zebrafish mutant [RNA-seq]
To determine the global impact of the clbn mutation on gene expression and efficiency of U2- and U12-type splicing, we analyzed the transcriptome of 108hpf wt and clbn mutant larvae by microarrays and RNA sequencing. RNAseq data was used to characterize intron retention of U2-type and U12-type intro...
ORGANISM(S): Danio rerio 
2014-02-05 | E-GEOD-53758 | biostudies-arrayexpress
UnknownDevelopment and Preliminary Validation of the Lovebird Scale.
Not available
S-EPMC11429147 | biostudies-literature
TranscriptomicsTranscriptome wide target profiling for miR-199a-5p and miR-424-3p.
Whole transcriptome Identification of direct targets of miR-199a-5p and miR-424-3p using biotinylated pull-downs found that both miRNAs are likely to have a role in the cell cycle. HEK293T cells were transfected with biotinylated miRNAs (either miR-199a-5p or miR-424-3p). The miRNAs and target mRNA...
ORGANISM(S): Homo sapiens 
2013-12-02 | E-GEOD-40406 | biostudies-arrayexpress
GenomicsKLF1/EKLF regulatory networks in primary erythroid cells
KLF1 (EKLF) regulates a diverse suite of genes to direct erythroid cell differentiation from bi-potent progenitors. To determine the local cis-regulatory contexts and transcription factor networks in which KLF1 operates, we performed KLF1 ChIP-seq in the mouse. We found at least 945 sites in the gen...
ORGANISM(S): Mus musculus 
2010-04-08 | E-GEOD-20478 | biostudies-arrayexpress
TranscriptomicsThe miRNA miR-139-5p is a regulator of metastatic pathways in breast cancer.
Whole transcriptome Identification of direct targets of miR-139-5p using biotinylated pull-downs found that this miRNA has roles in breast cancer invasion and migration. MCF7 cells were transfected with biotinylated miR-139-5p. The miRNAs and target mRNA were pulled down with streptavidin and compa...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-40411 | biostudies-arrayexpress
UnknownHigh-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations.
Not available
S-EPMC7002524 | biostudies-literature
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