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MetabolomicsMetabolomics Identifies Metabolic Markers of Maturation in Human Pluripotent Stem Cell-Derived Cardiomyocytes
Cardiovascular disease is a leading cause of death worldwide. Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) hold immense clinical potential and recent studies have enabled generation of virtually pure hPSC-CMs with high efficiency in chemically defined and xeno-free conditions. Despi...
2018-04-24 | MTBLS425 | MetaboLights
ProteomicsBlood biomarkers in a cohort of patients with CHRNE-associated congenital myasthenic syndrome
Pathogenic variants in CHRNE encoding the epsilon subunit of acetyl choline receptor (AChR) result in impaired neuromuscular transmission and congenital myasthenic syndromes (CMS). Clinical manifestations include facial, ocular and limb fatigability and weakness, whereby severity of symptoms may var...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054347 | Pride
Cms mirna Cms metabolites Cms biomarkers Plec Cms extracellular vesicles Cms white blood cells Cms amino acids 
ProteomicsNovel Insights into Candidate Biomarkers in Patients with Chronic Mountain Sickness Based on Proteomics
Chronic mountain sickness (CMS) is a progressive incapacitating syndrome induced by lifelong exposure to hypoxia. In the present study, proteomic analysis was used to identify the differential expression proteins (DEPs) and then evaluate the potential biomarkers between CMS and non-CMS groups. A tot...
ORGANISM(S): Homo Sapiens 
2020-10-22 | PXD022139 |
GenomicsPredicting Oncology Drug-Induced Cardiotoxicity with Donor-Specific iPSC-CMs – Model Verification with Doxorubicin
Predicting Oncology Drug-Induced Cardiotoxicity with Donor-Specific iPSC-CMs – Model Verification with Doxorubicin
PRJNA1014359 | ENA
TranscriptomicsPredicting Oncology Drug-Induced Cardiotoxicity with Donor-Specific iPSC-CMs – Model Verification with Doxorubicin
Many oncology drugs have been found to induce cardiotoxicity in a subset of patients, which significantly limits their clinical use and impedes the benefit of lifesaving anti-cancer treatments. Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) carry donor-specific genetic informa...
ORGANISM(S): Homo sapiens 
2024-09-07 | GSE242692 | GEO
UnknownPredicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs-a proof-of-concept study with doxorubicin.
Not available
S-EPMC11199917 | biostudies-literature
TranscriptomicsModeling acute myocardial infarction in vitro using mature and ventricular hESC-derived cardiomyocytes by FGF4 and ascorbic acid treatment
hPSC-CMs resemble immature embryonic or fetal CMs rather than mature adult CMs, and have limitations in disease modeling and pharmacological studies. Therefore, hPSCs-derived mature and ventricular CMs are required for more accurate in vitro modeling of adult-onset cardiac disease and drug discovery...
ORGANISM(S): Homo sapiens 
2021-04-11 | GSE171824 | GEO
ProteomicsProteomic characterization of the molecular signature of congenital myopathies
Congenital myopathies (CMs) are progressive diseases that constitute a diverse group of hereditary neuromuscular disorders that have been studied due to their diagnostic and therapeutic complexity. Due to the great clinical and molecular heterogeneity of CMs, this set of diseases constantly challeng...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD050694 | Pride
Proteomics Becker muscular dystrophy Duchenne muscular dystrophy Mass spectrometry Biomarkers 
UnknownCell migration simulator-based biomarkers for glioblastoma.
Not available
S-EPMC11600334 | biostudies-literature
UnknownChronic drug-induced effects on contractile motion properties and cardiac biomarkers in human induced pluripotent stem cell-derived cardiomyocytes.
Not available
S-EPMC5647189 | biostudies-literature
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