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TranscriptomicsThe human pancreatic islet transcriptome: impact of pro-inflammatory cytokines
We have used RNA-seq to identify transcripts, including splice variants, expressed in human islets of Langerhans under control condition or following exposure to the pro-inflammatory cytokines interleukin-1β (IL-1β) and interferon-γ (IFN-γ). A total of 29,776 transcripts were identified as expressed...
ORGANISM(S): Homo sapiens 
2012-03-09 | E-GEOD-35296 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate
Pancreatic beta-cell dysfunction and death are central in the pathogenesis of type 2 diabetes. Saturated fatty acids cause beta-cell failure and contribute to diabetes development in genetically predisposed individuals. Here we used RNA-sequencing to map transcripts expressed in five palmitate-treat...
ORGANISM(S): Homo sapiens 
2014-01-09 | E-GEOD-53949 | biostudies-arrayexpress
TranscriptomicsFunctional genomic analysis of frataxin deficiency, Illumina data
Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARγ pathway as a therapeutic target in Friedreich's ataxia Friedreich's ataxia (FRDA), the most common inherited ataxia, is characterized by focal neurodegeneration, diabetes mellitus, and l...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-15848 | biostudies-arrayexpress
TranscriptomicsFunctional genomic analysis of frataxin deficiency, Agilent data
Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARγ pathway as a therapeutic target in Friedreich's ataxia Friedreich's ataxia (FRDA), the most common inherited ataxia, is characterized by focal neurodegeneration, diabetes mellitus, and li...
ORGANISM(S): Mus musculus 
2009-06-02 | E-GEOD-15843 | biostudies-arrayexpress
TranscriptomicsEpigenome analysis of genomic DNA isolated from whole blood of non-diabetic control and type-2 diabetic individuals
DNA methylation profiling of whole blood using Illumina's Infinium HumanMethylation27 Beadchip array. The dataset encompasses profiles of 12 non-diabetic control blood donors and 12 type-2 diabetic (T2D) individuals. Bisulfite converted DNA from 24 blood samples were hybridised to the Illumina Infin...
ORGANISM(S): Homo sapiens 
2012-04-22 | E-GEOD-34008 | biostudies-arrayexpress
ProteomicsTime course treatment with Palmitate and thapsigargin of insulinoma INS-1E cells
Time course treatment with 0.4 mM Palmitate and 200 nM thapsigargin of insulinoma INS-1E cells. Timepoints; 0, 4, 16 and 24h in biological duplicates within an iTRAQ 8 set for palmitate and thapsigargin, respectively.
ORGANISM(S): Rattus Rattus (black Rat) 
2020-08-18 | PXD020851 | JPOST Repository
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