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ProteomicsAPOE4 cell-specific mechanisms underlying cerebrovascular disorder precede neuronal and synaptic dysfunction and cognitive deficits in mice
Apolipoprotein E4 (APOE4), the main susceptibly gene for Alzheimer’s disease1–5, exerts cerebrovascular toxicity6 leading to blood-brain barrier (BBB) breakdown in humans7–9 and APOE4 transgenic mice10–13. Moreover, an early BBB dysfunction predicts cognitive decline in humans7. However, the compre...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-23 | PXD029230 | Pride
Phosphoproteome Alzheimer’s disease Signaling networks Single cell rna-seq Apoe4 Bbb breakdown Interactome Blood-brain barrier 
ProteomicsMutations in the postsynaptic signaling hub TNIK disrupts neuronal progenitor cells and immature neuronal function in human models of neurodevelopmental disease
Synaptic proteins, in particular those connected in large protein interaction networks at the postsynaptic site of glutamatergic neurons have been associated to a number of neurodevelopmental disorders. While their contribution to disease has been well documented in mature rodent synapses, their rol...
ORGANISM(S): Homo sapiens (Human) 
2024-03-26 | PXD035004 | Pride
Neurodevelopment Hipsc Signaling networks Disease Postsynaptic Signaling 
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