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Multicellular Tumor Spheroids (MCTS) were pre-formed for 3 days with 786-O cell line to better mimic the tumor microenviroenment. These spheroids were treated with either vehicle (DMSO), drugs alone (KU-60019 10 μM; CX-4945 5 μM) or in combination (KU + CX) for 48h before RNA extraction.
ORGANISM(S): Homo sapiens 
To understand how CK2M-NM-2 silencing promotes a mesenchymal phenotype in human epithelial cells, like TGFM-NM-2 does, we have employed whole genome microarray expression profiling as a discovery platform to compare genes regulated in CK2M-NM-2-depleted cells and in TGFM-NM-2-treated cells. To do s...
ORGANISM(S): Homo sapiens 
The receptor for advanced glycation end products (RAGE) is a multiligand, immunoglobulin-like transmembrane protein expressed in various cell types and implicated in a broad spectrum of diseases linked with epithelial dysfunctions. Despite significant progress in structural studies, the details of i...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD064008 | Pride
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