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TranscriptomicsSuppression of p53-mediated senescence by non-canonical NF-kappaB pathway mediated regulation of EZH2 expression
The NF-kappaB and p53 transcription factors control the expression of complex gene regulatory networks in response to many cell stresses and stimuli. This experiment describes gene expression profiling of cells depleted for EZH2, NF-kappaB2, RelB and p53. We find that EZH2 is the major effector of c...
ORGANISM(S): Homo sapiens 
2014-03-31 | E-MTAB-1593 | biostudies-arrayexpress
TranscriptomicsZinc sensing by metal-responsive transcription factor 1 (MTF1) controls metallothionein and ZnT1 expression to buffer the sensitivity of the transcriptome response to zinc
Only a small number of genes are known direct targets of the zinc-responsive transcription factor MTF1; therefore, the aim of this study was to gain a more complete understanding of the MTF-1 regulated zinc-responsive component of the transcriptome. A targeted siRNA was used to deplete MTF1 express...
ORGANISM(S): Homo sapiens 
2016-02-24 | E-GEOD-76510 | biostudies-arrayexpress
TranscriptomicsPositive and negative regulation of lymphomagenesis by the NF-kappaB subunit c-Rel
'The REL gene, encoding the NF-κB subunit c-Rel, is frequently amplified in B-cell lymphoma and functions as a tumour promoting transcription factor. Here we report the surprising result that c-rel -/- mice display significantly earlier lymphomagenesis in the c-Myc driven, Eμ-Myc model of B-cell lym...
ORGANISM(S): Mus musculus 
2014-12-31 | E-MTAB-2774 | biostudies-arrayexpress
TranscriptomicsComparison of pan-inhibitor of HDACS (TSA) to specific HDAC8 inhibitor (HDAC Inhibitor XIX, Compound 2) in human myometrium
To compare gene expression in human myometrium after TSA treatment to gene expression after treatment with a specific HDAC8 inhibitor Four Control, four TSA and four Compound 2 samples (2 patients, replicated) derived from non-pregnant myometrial strips
ORGANISM(S): Homo sapiens 
2012-02-07 | E-GEOD-27124 | biostudies-arrayexpress
TranscriptomicsHuman CD4+ T-cell transcriptome in early arthritis
An exploration of the peripheral blood CD4+ T-cell transcriptome of early arthritis clinic attendees, seeking novel diagnostic tools and pathophysiological insights. Ex-vivo CD4+ T-cell RNA was obtained following first early arthritis clinic attendance from 173 patients. Four diagnostic categories ...
ORGANISM(S): Homo sapiens 
2012-03-03 | E-GEOD-20098 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of epithelial and fibroblast cells in chronic rhinosinusitis
Chronic rhinosinusitis without polyps (CRSsNP) is typified by inflammation of the sinonasal epithelium and the development of fibrosis. The precise pathophysiology of this common condition remains elusive. Here we aim to investigate the transcriptome (RNA transcripts in the cell) of the component ...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-69093 | biostudies-arrayexpress
TranscriptomicsA transcriptional signature of fatigue derived from patients with primary Sjögren's Syndrome
Fatigue is a debilitating condition with a significant impact on patients’ quality of life. Fatigue is frequently reported by patients suffering from primary Sjo ̈gren’s Syndrome (pSS), a chronic autoimmune condition characterised by dryness of the eyes and the mouth. However, although fatigue ...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-66795 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of a gut epithelial cell line after the depletion of selenoprotein Glutathione peroxidase 4
GPx4 is an important antioxidant gene that is derived from selenium. A ploymorphism in GPx4 has been associated with increased risk of colorectal and prostate cancer. This experiment decsribes the effect of change in GPx4 expression in human intestinal epithelial cell line (Caco-2).Depletion of GPx4...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-40287 | biostudies-arrayexpress
GenomicsGenome wide ChIP-seq analysis of human TOP2B occupancy in MCF7 breast cancer epithelial cells
TOP2B is involved in transcriptional initiation in response to nuclear hormone ligands and plays a role in transcriptional elongation. Whole genome TOP2B ChIP-seq was carried out on human MCF7 cells in the presence and absence of the nuclear hormone estradiol. Three peak calling methods were used an...
ORGANISM(S): Homo sapiens 
2015-09-21 | E-GEOD-66753 | biostudies-arrayexpress
TranscriptomicsContribution of natural antisense transcription to an endogenous siRNA signature in human cells
Background: Eukaryotic cells express a complex layer of noncoding RNAs. An intriguing family of regulatory RNAs includes transcripts from the opposite strand of protein coding genes, so called natural antisense transcripts (NATs). Here, we test the hypothesis that antisense transcription triggers RN...
ORGANISM(S): Homo sapiens 
2014-02-28 | E-GEOD-52996 | biostudies-arrayexpress
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