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ProteomicsMaximizing Heterologous Expression of Engineered Type I Polyketide Synthases: Investigating Codon Optimization Strategies
Type I polyketide synthases (T1PKSs) hold an enormous potential as a rational production platform for the biosynthesis of speciality chemicals. However, despite the great progress in this field, the heterologous expression of PKSs remains a major challenge. One of the first measures to improve heter...
ORGANISM(S): Corynebacterium glutamicum Escherichia coli Pseudomonas putida KT2440 
2023-09-01 | PXD042749 | Pride
Codon optimization Heterologous expression Polyketide synthases 
GenomicsCodon usage optimization in pluripotent embryonic stem cells [tRNA sequencing]
Codon usage optimization in pluripotent embryonic stem cells [tRNA sequencing]
PRJNA509375 | ENA
GenomicsCodon usage optimization in pluripotent embryonic stem cells [RNA-seq]
Codon usage optimization in pluripotent embryonic stem cells [RNA-seq]
PRJNA439265 | ENA
TranscriptomicsOptimization of codon translation rates via tRNA modifications maintains proteome integrity
Proteins begin to fold as they emerge from translating ribosomes. The kinetics of ribosome transit along a given mRNA can influence nascent chain folding, but the extent to which individual codon translation rates impact proteome integrity remains unknown. Here, we show that slower decoding of discr...
ORGANISM(S): Caenorhabditis elegans 
2015-06-04 | E-GEOD-67387 | biostudies-arrayexpress
TranscriptomicsCodon usage optimization in pluripotent embryonic stem cells [RNA-seq]
The uneven use of synonymous codons in the transcriptome regulates the efficiency and fidelity of protein translation rates. Yet, the importance of this codon bias on regulating cell state-specific expression programs is currently debated. Here, we asked whether the gene expression program in the we...
ORGANISM(S): Homo sapiens 
2019-05-17 | GSE112085 | GEO
OtherCodon usage optimization in pluripotent embryonic stem cells [tRNA sequencing]
The uneven use of synonymous codons in the transcriptome regulates the efficiency and fidelity of protein translation rates. Yet, the importance of this codon bias on regulating cell state-specific expression programs is currently debated. Here, we asked whether the gene expression program in the we...
ORGANISM(S): Homo sapiens 
2019-05-17 | GSE123608 | GEO
GenomicsCodon usage optimization in pluripotent embryonic stem cells
Codon usage optimization in pluripotent embryonic stem cells
PRJNA509373 | ENA
GenomicsOptimization of codon translation rates via tRNA modifications maintains proteome integrity
Optimization of codon translation rates via tRNA modifications maintains proteome integrity
PRJNA279785 | ENA
ProteomicsCodon Optimization Introduces Hidden Frameshifting Risk in Protein-Coding Nucleic Acid Therapeutics
The therapeutic promise of protein-coding genetic medicines depends on accurate translation of designed nucleic acid sequences into functional proteins. Here we reveal that current design practices systematically deplete stop codons from alternative reading frames, creating an unrecognized risk of o...
ORGANISM(S): Homo Sapiens 
2026-01-18 | PXD073231 |
UnknownCodon optimization underpins generalist parasitism in fungi.
Not available
S-EPMC5315462 | biostudies-literature
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