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MetabolomicsGut Microbiota-Mediated Conversion of Coenzyme A in Vitro

The bacterium Roseburia inulinivorans harbors enzymes predicted to be involved in coenzyme A (CoA) metabolism. To experimentally validate the source of pantetheine, we performed an in vitro co-culture of R. inulinivorans with CoA and analyzed metabolomic profiles. The results demonstrated a signi...

2025-10-15 | MTBLS13143 | MetaboLights
TranscriptomicsGene expression in the mitochondrial syndrome of coenzyme Q deficiency
Coenzyme Q10 deficiency syndrome includes a clinically heterogeneous group of mitochondrial diseases characterized by low content of CoQ10 in tissues. The only currently available treatment is supplementation with CoQ10, which improves the clinical phenotype in some patients but does not reverse est...
ORGANISM(S): Homo sapiens 
2013-04-05 | E-GEOD-33940 | biostudies-arrayexpress
Metabolomics2,3,7,8 -Tetrachlorodibenzo-p-dioxin Mediated Effects on Hepatic Coenzyme A (CoA) and Acetyl-CoA Levels (part-I)
Not available
ORGANISM(S): Mus musculus 
ST001376 | MetabolomicsWorkbench
Metabolomics2,3,7,8 -Tetrachlorodibenzo-p-dioxin Mediated Effects on Hepatic Coenzyme A (CoA) and Acetyl-CoA Levels (part-II)
Not available
ORGANISM(S): Mus musculus 
ST001379 | MetabolomicsWorkbench
TranscriptomicsCommon gene expression profile in the mitochondrial syndrome of coenzyme Q deficiency
Coenzyme Q10 deficiency syndrome includes a clinically heterogeneous group of mitochondrial diseases characterized by low content of CoQ10 in tissues. The only currently available treatment is supplementation with CoQ10, which improves the clinical phenotype in some patients but does not reverse est...
ORGANISM(S): Homo sapiens 
2013-04-05 | E-GEOD-33769 | biostudies-arrayexpress
TranscriptomicsCoenzyme Q10-dependent gene expression in SAMP1 mice tissues
Our present study reveals significant decelerating effects on senescence processes in middle-aged SAMP1 mice supplemented for 6 or 14 months with the reduced form (QH2, 500 mg/ kg BW/ day) of coenzyme Q10 (CoQ10). To unravel molecular mechanisms of these CoQ10 effects, a genome-wide transcript profi...
ORGANISM(S): Mus musculus 
2010-03-15 | E-GEOD-15129 | biostudies-arrayexpress
GenomicsCoenzyme A biosynthesis in Bacillus subtilis: Discovery of a novel precursor metabolite for salvage and its uptake system
Coenzyme A biosynthesis in Bacillus subtilis
PRJEB77606 | ENA
ProteomicsInvestigating peptide-Coenzyme A-conjugates as chemical probes for proteomic profiling of N-terminal and lysine acetyltransferases
Acetyl groups are transferred from Acetyl-Coenzyme A (Ac-CoA) to protein N-termini and lysine side chains by N-terminal acetyltransferases (NATs) and lysine acetyltransferases (KATs), respectively. Building on lysine-CoA conjugates as KAT probes, we have synthesized peptide probes with CoA conjugate...
ORGANISM(S): Homo Sapiens (human) 
2022-05-02 | PXD032957 | JPOST Repository
MetabolomicsThermal Profiling Maps Multilayered Organization of the Mitochondrial Proteome

Mitochondria execute essential metabolic, biosynthetic, and signaling functions, yet the regulatory principles governing their proteome remain incompletely understood. Here, we develop a thermal proteome profiling (TPP) workflow applied directly to purified mitochondria, enabling systematic analy...

2025-12-08 | MTBLS7386 | MetaboLights
GenomicsImplication of Acyl Coenzyme A Binding Protein (ACBP) in Cushing Syndrome
Implication of Acyl Coenzyme A Binding Protein (ACBP) in Cushing Syndrome
PRJNA1045563 | ENA
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