Cohen Todd J TJ

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Mass Spectrometry (2)
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Department of Neurology, University of North Carolina, Chapel Hill, NC, USA (1)
Associate Professor, Department of Neurology, UNC-Chapel Hill (1)

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ALS-associated TDP-43 aggregates drive innate and adaptive immune cell activation

Amyotrophic lateral sclerosis is the most common and fatal motor neuron disease. Approximately 90% of ALS patients exhibit pathology of the master RNA regulator, Transactive Response DNA Binding protein (TDP-43). Despite the prevalence TDP-43 pathology in ALS motor neurons, recent findings suggest i...

ORGANISM(S): Homo sapiens (Human)

2025-04-08 | PXD062260 | Pride

Tdp-43 Als

Acetylation Regulates MARK2 activity

This study investigates the interactions between two enzymes involved in regulating the protein tau’s PTMs: the kinase MARK2 and the acetyltransferase CBP. Western blot analysis revealed that CBP-mediated acetylation was increased in the absence of MARK2, indicating a possible negative feedback loop...

ORGANISM(S): Homo sapiens (Human)

2022-06-09 | PXD030937 | Pride

Mark2 Phosphorylation

Increasing frailty is associated with higher prevalence and reduced recognition of delirium in older hospitalised inpatients: results of a multi-centre study.

Not available

S-EPMC10113325 | biostudies-literature

Intensive vs Standard Treatment of Hyperglycemia and Functional Outcome in Patients With Acute Ischemic Stroke: The SHINE Randomized Clinical Trial.

Not available

S-EPMC6652154 | biostudies-literature

Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.

Not available

S-EPMC7884931 | biostudies-literature