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GenomicsReduced representation bisulfite sequencing from G0 & G4/G5 CMP
Differential hyper- and hypo-methylation regions in G0 versus G4/G5 CMP The goal of this study is to evaluate changes in CpG methylation profilings of telomere dysfunctional common myeloid progenitor cells (CMP) as compared to their wild type controls Genomic DNA was extracted from sorted CMP popula...
ORGANISM(S): Mus musculus 
2015-04-09 | E-GEOD-62392 | biostudies-arrayexpress
TranscriptomicsExpression data from G0 versus G4/G5 CMP/GMP
Telomere dysfunctional CMP/GMP have deregulated pathways that are associated with DNA damage signaling We compared differentially expressed genes in the G4/G5 CMP relative to the G0 control to identify pathways that may affect CMP differentiation. Bone marrow CMP and GMP cells were sorted from two p...
ORGANISM(S): Mus musculus 
2015-04-09 | E-GEOD-62278 | biostudies-arrayexpress
TranscriptomicsStudy of Bacillus cereus spore germination and outgrowth in a vegetable food model by means of genome-wide transcriptome analysis
Pathogenic species belonging to Bacillus cereus sensu lato group possess a high evolutionary advantage in the environment and in food matrices thanks to their capacity to survive as silent spores to harsh environmental insults and grow at relatively low temperatures. Ready to re-heat products are at...
ORGANISM(S): Bacillus cereus 
2015-01-26 | E-GEOD-65259 | biostudies-arrayexpress
TranscriptomicsHypoxia-inducible factor (Hif)-1 knockdown blocks tumor growth, myeloma-induced angiogenesis and bone destruction in vivo
In multiple myeloma (MM), hypoxia-inducible transcription factor-1 (HIF-1) is overexpressed in the MM cells of the hypoxic bone marrow (BM) microenvironment. Herein, we explored in MM cells the in vitro and in vivo effects of persistent HIF-1 inhibition by expression of a lentivirus shRNA pool on pr...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-GEOD-40326 | biostudies-arrayexpress
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