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The role of Snail1 in collective migration
Gene expression of basal alonal, luminal alonal, basal and luminal aggregates during collective migration
Gene expression analysis to investigate role of tumor-intrinsic hypoxia and tumor secretome in collective migration
Snail1 is a transcription factor directly associated with epithelial-mesenchymal transition (EMT), but our study reveals its significant role in the collective migration process beyond EMT. Through sequencing, we found that knockdown of Snail1 weakens intercellular connections during migration and d...
ORGANISM(S): Mus musculus 
2026-05-01 | GSE296475 | GEO
We investigated two microenvironmental factors, tumor-intrinsic hypoxia, and tumor-secreted factors (secretome) as triggers of collective migration using a three-dimensional (3D) discrete-sized microtumor models that recapitulate hallmarks of Ductal carcinoma in situ (DCIS) to invasive ductal carcin...
ORGANISM(S): Homo sapiens 
2021-03-26 | GSE166211 | GEO
RhoA GEF Mcf2lb regulates rosette integrity during collective cell migration
The IKK kinase was previously found to activate multiple oncogenic and therapy-resistance pathways, including ATM/DDR, BRD4, and JAK/STAT3, independently of canonical NF-B signaling. Here, we show that suppression of IKK, either genetically or pharmacologically, imposes a pro-metastatic activity on ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-01 | PXD057102 | Pride
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