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GenomicsActive STAT5 in CD8 T cells imprints a T-Bet-dependent Tc-1 program with repressed IL-6/ TGFb1 signaling leading to enhanced anti-tumor responses
CD8 T cells (TCs) expressing active STAT5 (STAT5CA) transcription factors were found to be superior to un-manipulated counterparts in their long-term persistence, capacity to infiltrate a tumor, thrive in its microenvironment and induce its regression. STAT5CA induced sustained expression of genes c...
ORGANISM(S): Mus musculus 
2013-09-13 | E-GEOD-41818 | biostudies-arrayexpress
UnknownEvaluating phenotype-driven approaches for genetic diagnoses from exomes in a clinical setting.
Not available
S-EPMC5647373 | biostudies-literature
UnknownAssociations of Novel Dietary and Lifestyle Inflammation Scores With Incident Colorectal Cancer in the NIH-AARP Diet and Health Study.
Not available
S-EPMC7236782 | biostudies-literature
TranscriptomicsMolecular Characterization of the Vasculature of Patients with Infiltrating Ductal Carcinoma generates a Gene Signature predictive of Breast Cancer Survival
Introduction: Targeting of the tumor vasculature has evolved into an integral part of existing standard anti-cancer therapies. However, recent pre-clinical and clinical studies have shown that the efficacy of these treatments is temporary at most and frequently followed by the renewed tumor growth, ...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-GEOD-43379 | biostudies-arrayexpress
UnknownPrevalence and Correlates of Cardiovascular, Pulmonary, Cancer, and Mental Health Comorbidities Among Adults With HIV Who Smoke.
Not available
S-EPMC10803179 | biostudies-literature
UnknownSystematic, comprehensive, evidence-based approach to identify neuroprotective interventions for motor neuron disease: using systematic reviews to inform expert consensus.
Not available
S-EPMC9896226 | biostudies-literature
UnknownWorldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK).
Not available
S-EPMC10403688 | biostudies-literature
GenomicsGoT2D: Genetics of Type 2 Diabetes, a study of the the genetic architecture of type 2 diabetes using low pass whole genome sequencing and high density SNP genotyping in 2,657 individuals.
The Genetics of Type 2 Diabetes Consortium (GoT2D) is a collaboration between the University of Michigan, the Broad Institute and the Wellcome Trust Centre for Human Genetics. The overall aim is to extend upon recent efforts, such as genome-wide association studies (GWAS) and large scale meta-analys...
EGAS00001001459 | EGA
UnknownNeoadjuvant pembrolizumab plus chemotherapy followed by adjuvant pembrolizumab compared with neoadjuvant chemotherapy alone in patients with early-stage non-small-cell lung cancer (KEYNOTE-671): a randomised, double-blind, placebo-controlled, phase 3 trial.
Not available
S-EPMC11512588 | biostudies-literature
UnknownEffect of Minimally Invasive Surfactant Therapy vs Sham Treatment on Death or Bronchopulmonary Dysplasia in Preterm Infants With Respiratory Distress Syndrome: The OPTIMIST-A Randomized Clinical Trial.
Not available
S-EPMC8715350 | biostudies-literature
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