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TranscriptomicsA growth-essential Tetrahymena Piwi protein carries tRNA fragment cargo
Argonaute/Piwi proteins associate with small RNAs that typically provide sequence specificity for RNP function in gene and genome regulation. Here we show that Twi12, a Tetrahymena Piwi protein essential for growth, is loaded with mature tRNA fragments. The tightly bound ~18-22 nt tRNA 3M-bM-^@M-^Y ...
ORGANISM(S): Tetrahymena thermophila 
2010-10-26 | E-GEOD-24916 | biostudies-arrayexpress
GenomicsStretch-Enhancers Delineate Disease-Associated Regulatory Nodes in T Cells
T Cell stretch-enhancers are vulnerable to Jak inhibitor tofacitinib Treatment of T cells with the Janus kinase (JAK) inhibitor, tofacitinib, disproportionately altered the expression of RA risk genes with stretech-enhancer (SE) structures.
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-60482 | biostudies-arrayexpress
UnknownPOLR1B and neural crest cell anomalies in Treacher Collins syndrome type 4.
Not available
S-EPMC7056642 | biostudies-literature
TranscriptomicsDiscovery of novel recurrent mutations and rearrangements in early T-cell precursor acute lymphoblastic leukemia by whole genome sequencing
Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole genome sequencing of tumour and normal DNA from 12 children with ETP ALL and assessed the frequency of somatic alterations in 52 ETP and 42 non-ETP T-ALL samples by...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-28703 | biostudies-arrayexpress
UnknownReply to the Letter to the Editor: Stem Cells Combined With Platelet-rich Plasma Effectively Treat Corticosteroid-induced Osteonecrosis of the Hip: A Prospective Study.
Not available
S-EPMC5916597 | biostudies-literature
TranscriptomicsDevelopment pathway for skin resident memory CD103+CD8+ T cells
Tissue resident memory T cells (TRM) provide superior protection against infection localised to extra-lymphoid compartments in the body. Here we show that CD103+CD8+ TRM cells develop in skin from killer cell lectin-like receptor (KLR)G1-negative precursors that selectively infiltrate the epithelia...
ORGANISM(S): Mus musculus 
2013-10-01 | E-GEOD-47045 | biostudies-arrayexpress
UnknownAssociation of primary open-angle glaucoma with mitochondrial variants and haplogroups common in African Americans.
Not available
S-EPMC4872278 | biostudies-literature
TranscriptomicsTranscription profiling of mouse hematopoietic cells at different differentiation stages: hematopoietic stem cells (HSCs), progenitor cells (HPCs), and granulocytes somatic cells are more efficient than adult stem cells for cloning by somatic cell nuclear transfer
Since the creation of Dolly, the first sheep cloned via somatic cell nuclear transfer (SCNT), in 1997, more than a dozen species of mammals have been cloned using this technology. One hypothesis for the limited success of cloning via SCNT (1-5%) is that the clones are likely derived from adult stem...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5677 | biostudies-arrayexpress
TranscriptomicsMolecular Characterization of the Vasculature of Patients with Infiltrating Ductal Carcinoma generates a Gene Signature predictive of Breast Cancer Survival
Introduction: Targeting of the tumor vasculature has evolved into an integral part of existing standard anti-cancer therapies. However, recent pre-clinical and clinical studies have shown that the efficacy of these treatments is temporary at most and frequently followed by the renewed tumor growth, ...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-GEOD-43379 | biostudies-arrayexpress
UnknownIdentification of a miRNA-mRNA Regulatory Networks in Placental Tissue Associated With Tibetan High Altitude Adaptation.
Not available
S-EPMC8460760 | biostudies-literature
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